2022
Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
Hu X, Zhao J, Lin Z, Wang Y, Peng H, Zhao H, Wan X, Yang C. Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2106858119. PMID: 35787050, PMCID: PMC9282238, DOI: 10.1073/pnas.2106858119.Peer-Reviewed Original ResearchMeSH KeywordsCausalityGenetic PleiotropyGenome-Wide Association StudyMendelian Randomization AnalysisPhenotypeReproducibility of Results
2001
Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data
Zhang S, Pakstis A, Kidd K, Zhao H. Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data. American Journal Of Human Genetics 2001, 69: 906-912. PMID: 11536083, PMCID: PMC1226079, DOI: 10.1086/323622.Peer-Reviewed Original Research
2000
Assessing reliability of gene clusters from gene expression data
Zhang K, Zhao H. Assessing reliability of gene clusters from gene expression data. Functional & Integrative Genomics 2000, 1: 156-173. PMID: 11793234, DOI: 10.1007/s101420000019.Peer-Reviewed Original ResearchConceptsStatistical resampling methodsHierarchical clustering methodCluster identification methodNumerical algorithmGene expression dataClustering methodClustering treesResampling methodHierarchical clustering algorithmExpression dataExperiment designClustering algorithmAlgorithmChallenging problemData setsMeasured gene expression levelsEffect of variationData analysisClustersUncertaintyProblemReliability