Featured Publications
Integration of expression QTLs with fine mapping via SuSiE.
Zhang X, Jiang W, Zhao H. Integration of expression QTLs with fine mapping via SuSiE. PLOS Genetics 2024, 20: e1010929. PMID: 38271473, PMCID: PMC10846745, DOI: 10.1371/journal.pgen.1010929.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingGenome-Wide Association StudyLinkage DisequilibriumPhenotypePolymorphism, Single NucleotideQuantitative Trait LociConceptsExpression quantitative trait lociGenome-wide association studiesFine-mapping methodsLinkage disequilibriumBody mass indexFine-mappingExpression quantitative trait loci informationGenome-wide association study resultsExpression quantitative trait loci analysisPresence of linkage disequilibriumExternal reference panelGenetic fine-mappingQuantitative trait lociPosterior inclusion probabilitiesInclusion probabilitiesAlzheimer's diseaseExpression QTLsLD patternsComplex traitsCandidate variantsAssociation studiesTrait lociAssociation to causationReference panelFunctional variants
2017
Leveraging functional annotations in genetic risk prediction for human complex diseases
Hu Y, Lu Q, Powles R, Yao X, Yang C, Fang F, Xu X, Zhao H. Leveraging functional annotations in genetic risk prediction for human complex diseases. PLOS Computational Biology 2017, 13: e1005589. PMID: 28594818, PMCID: PMC5481142, DOI: 10.1371/journal.pcbi.1005589.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingData Interpretation, StatisticalData MiningDatabases, GeneticEpigenomicsGenetic Association StudiesGenetic Predisposition to DiseaseGenetic VariationGenome, HumanHumansLinkage DisequilibriumPolymorphism, Single NucleotideProportional Hazards ModelsQuantitative Trait LociRisk AssessmentConceptsGenome-wide association studiesFunctional annotationGenetic risk predictionDisease-associated genetic variantsLinkage disequilibriumIdentification of thousandsWide association studyHuman complex diseasesComplex diseasesGWAS summary statisticsHuman genetics researchAssociation studiesAnnoPredGenotype dataGenetic researchGenetic variantsRelevant variantsAnnotationDisequilibriumMost diseasesDiverse typesSummary statisticsVariantsBayesian frameworkPrecision medicine
2001
Multipoint Genetic Mapping with Trisomy Data
Li J, Sherman S, Lamb N, Zhao H. Multipoint Genetic Mapping with Trisomy Data. American Journal Of Human Genetics 2001, 69: 1255-1265. PMID: 11704925, PMCID: PMC1235537, DOI: 10.1086/324578.Peer-Reviewed Original ResearchConceptsExpectation-maximization algorithmMultipoint genetic mappingAmount of computationProbability distributionTrisomy dataStatistical methodsFirst approachMarkov modelSecond approachProbabilityCrossover processComputationLarge numberSetModelApproachGeneral relationshipDistributionAlgorithmNumber of markersTest of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test
Zhang S, Zhang K, Li J, Sun F, Zhao H. Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test. Genetic Epidemiology 2001, 21: s370-s375. PMID: 11793701, DOI: 10.1002/gepi.2001.21.s1.s370.Peer-Reviewed Original ResearchConceptsQuantitative pedigree disequilibrium testPedigree disequilibrium testQuantitative traitsTraits of interestGenetic Analysis Workshop 12Disequilibrium testGeneral pedigreesSequence dataCandidate genesGenetic markersGenetic linkageQualitative traitsLinkage disequilibriumTraitsLarge pedigreePresence of linkagePedigreeStatistical methodsFamilyNuclear familiesTests of associationGenesUnrelated nuclear familiesLinkageDisequilibrium
2000
Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers
Zhao H, Zhang S, Merikangas K, Trixler M, Wildenauer D, Sun F, Kidd K. Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers. American Journal Of Human Genetics 2000, 67: 936-946. PMID: 10968775, PMCID: PMC1287895, DOI: 10.1086/303073.Peer-Reviewed Original ResearchMultipoint Genetic Mapping with Uniparental Disomy Data
Zhao H, Li J, Robinson W. Multipoint Genetic Mapping with Uniparental Disomy Data. American Journal Of Human Genetics 2000, 67: 851-861. PMID: 10958760, PMCID: PMC1287890, DOI: 10.1086/303072.Peer-Reviewed Original ResearchLinkage disequilibrium mapping in populations of variable size using the decay of haplotype sharing and a stepwise‐mutation model
Zhang S, Zhao H. Linkage disequilibrium mapping in populations of variable size using the decay of haplotype sharing and a stepwise‐mutation model. Genetic Epidemiology 2000, 19: s99-s105. PMID: 11055377, DOI: 10.1002/1098-2272(2000)19:1+<::aid-gepi15>3.0.co;2-1.Peer-Reviewed Original Research
1997
Strategies to Identify Genes for Complex Diseases
Zhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.Peer-Reviewed Original ResearchConceptsComplex diseasesNumerous human diseasesDisease-susceptible genesComplex human disordersHuman genomeGenetic basisHuman disordersHuman diseasesMolecular biologyGenesGenetic epidemiological studiesGenetic factorsComplex patternsDisease pathophysiologyGenomeBiologyTraitsInheritanceMultiple sclerosisBreast cancerEpidemiological studies
1996
On Genetic Map Functions
Zhao H, Speed T. On Genetic Map Functions. Genetics 1996, 142: 1369-1377. PMID: 8846913, PMCID: PMC1207133, DOI: 10.1093/genetics/142.4.1369.Peer-Reviewed Original ResearchChromosome MappingModels, Genetic
1995
Relative Efficiencies of χ2 Models of Recombination for Exclusion Mapping and Gene Ordering
Goldstein D, Zhao H, Speed T. Relative Efficiencies of χ2 Models of Recombination for Exclusion Mapping and Gene Ordering. Genomics 1995, 27: 265-273. PMID: 7557991, DOI: 10.1006/geno.1995.1041.Peer-Reviewed Original Research