2009
Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming
Bromer JG, Wu J, Zhou Y, Taylor HS. Hypermethylation of Homeobox A10 by in Utero Diethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming. Endocrinology 2009, 150: 3376-3382. PMID: 19299448, PMCID: PMC2703508, DOI: 10.1210/en.2009-0071.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDiethylstilbestrolDNA (Cytosine-5-)-MethyltransferasesDNA MethylationEpigenesis, GeneticFemaleGene Expression Regulation, DevelopmentalGenes, HomeoboxHomeobox A10 ProteinsHomeodomain ProteinsHumansMiceMolecular Sequence DataPregnancyPrenatal Exposure Delayed EffectsUterusConceptsDES exposureHOXA10 expressionDevelopmental programmingUtero DES exposureUtero diethylstilbestrol exposureHuman endometrial cellsExpression of HOXA10Homeobox gene HOXA10Female reproductive tractDiethylstilbestrol exposureEndometrial cellsClassical estrogenHomeobox A10Short-term exposureDNA methyltransferases 1Uterine organogenesisDevelopmental anomaliesCaudal portionIncreased expressionHOXA10 geneReproductive tractNonsteroidal estrogensEpigenetic mechanismsExposure resultsDiethylstilbestrol
2006
Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development
Smith CC, Taylor HS. Xenoestrogen exposure imprints expression of genes (Hoxa10) required for normal uterine development. The FASEB Journal 2006, 21: 239-246. PMID: 17093138, DOI: 10.1096/fj.06-6635com.Peer-Reviewed Original ResearchConceptsHOXA10 estrogen response elementEstrogen response elementHOXA10 expressionUterine developmentAbility of BPAReproductive tract alterationsUterine HOXA10 expressionUtero BPA exposureER antagonist ICIExpression of HOXA10Gestational day 9Normal uterine developmentDose-responsive increaseDose-response increaseHOXA10 mRNA expressionHOXA10 antisenseUtero exposureAntagonist ICITract alterationsBPA exposureIshikawa cellsBPA actionEstrogen stimulationEndocrine perturbationsDay 9