2024
Modeling the Determinants of Subjective Well-Being in Schizophrenia
Jeong J, Kim J, Kang N, Ahn Y, Kim Y, Lee D, Kim H. Modeling the Determinants of Subjective Well-Being in Schizophrenia. Schizophrenia Bulletin 2024, sbae156. PMID: 39255414, DOI: 10.1093/schbul/sbae156.Peer-Reviewed Original ResearchObsessive-compulsive symptomsSubjective well-beingDeterminants of subjective well-beingLevels of subjective well-beingStructural equation modelingPsychotic symptomsPrediction of subjective well-beingNeuroleptic Treatment ScaleTreatment of schizophreniaMediation of depressionStructural equation modeling analysisCut-off scoreWell-beingMaintained 6 monthsSchizophrenia treatmentCognitive deficitsSchizophreniaReduce distressTreatment ScaleRelationship patternsArea under the curveSomatizationDepressionEquation modelingIndirect effectsAuthor Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae M, Roh J, Kim Y, Kim S, Han H, Yang E, Kang H, Lee S, Kim J, Kang R, Jung H, Yoo T, Kim H, Kim D, Oh H, Han S, Kim D, Han J, Bae Y, Kim H, Ahn S, Chan A, Lee D, Kim J, Kim E. Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Molecular Medicine 2024, 16: 2653-2653. PMID: 39242973, PMCID: PMC11473947, DOI: 10.1038/s44321-024-00125-y.Peer-Reviewed Original ResearchLoss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice
Kang R, Kim K, Jung Y, Choi S, Lee C, Im G, Shin M, Ryu K, Choi S, Yang E, Shin W, Lee S, Lee S, Papadopoulos Z, Ahn J, Koh G, Kipnis J, Kang H, Kim H, Cho W, Park S, Kim S, Kim E. Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice. PLOS Biology 2024, 22: e3002596. PMID: 38718086, PMCID: PMC11104772, DOI: 10.1371/journal.pbio.3002596.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral phenotypesASD-relatedSocial communication deficitsAutism-related phenotypesEnlarged lateral ventriclesProgressive ventricular enlargementCommunication deficitsSpectrum disorderSynaptic deficitsEnlargement of brain ventriclesTranscriptomic changesMicrotubule-regulatory proteinsGenes down-regulatedBrain ventriclesVentricular enlargementLateral ventricleDeficitsHippocampal neuronsMotile ciliaKATNAL2Potential treatmentDown-regulationCiliary functionEpendymal cellsComparative Study of the Efficacy and Side Effects of Brand-Name and Generic Clozapine for Long-Term Maintenance Treatment Among Korean Patients With Schizophrenia: A Retrospective Naturalistic Mirror-Image Study
Kang N, Yoon H, Kim H, Jeong J, Kim M, Kwon J. Comparative Study of the Efficacy and Side Effects of Brand-Name and Generic Clozapine for Long-Term Maintenance Treatment Among Korean Patients With Schizophrenia: A Retrospective Naturalistic Mirror-Image Study. Psychiatry Investigation 2024, 21: 311-320. PMID: 38569589, PMCID: PMC10990625, DOI: 10.30773/pi.2023.0413.Peer-Reviewed Original ResearchMirror-image studyMaintenance treatmentTreatment-resistant schizophreniaFormulation of clozapineLong-term maintenance treatmentConcentration-to-dose ratioClozapine useGeneric clozapineClozapineClozarilPsychiatric hospitalNo significant differenceSchizophreniaKorean patientsMedical records of patientsClinical insightsBlood test findingsElectronic medical records of patientsSignificant differenceRecords of patientsBrand-name formulationConcomitant medicationsCo-medicationHospitalization durationLaboratory findings
2023
Key Word Analysis Study on Depression and Anxiety Using Social Big Data During the (COVID)-19 Pandemic in Korea
Lee C, Kim H, Ahn B, Son S. Key Word Analysis Study on Depression and Anxiety Using Social Big Data During the (COVID)-19 Pandemic in Korea. American Journal Of Health Behavior 2023, 47: 68-78. DOI: 10.5993/ajhb.47.6.7.Peer-Reviewed Original Research
2014
Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex
Park H, Yu H, Park S, Ahn Y, Kim Y, Kim H. Repeated treatment with electroconvulsive seizures induces HDAC2 expression and down-regulation of NMDA receptor-related genes through histone deacetylation in the rat frontal cortex. The International Journal Of Neuropsychopharmacology 2014, 17: 1487-1500. PMID: 24606669, DOI: 10.1017/s1461145714000248.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnalysis of VarianceAnimalsButyric AcidChromatin ImmunoprecipitationDisease Models, AnimalElectroshockFrontal LobeGene Expression RegulationGlial Fibrillary Acidic ProteinHistamine AntagonistsHistone Deacetylase 2MalePhosphopyruvate HydrataseRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateRNA, MessengerSeizuresSignal TransductionConceptsSignaling-related genesHistone deacetylasesHistone modificationsHistone acetylationCalcium/calmodulin-dependent protein kinase II alphaChromatin immunoprecipitation analysisRat frontal cortexEarly growth response 1Transcriptional repressionReceptor-related genesHistone deacetylationH4 proteinN-methyl-D-aspartate 2ATarget genesFrontal cortexImmunoprecipitation analysisElectroconvulsive seizuresGene expressionResponse 1GenesHDAC2 expressionNeuronal cellsECS treatmentClass I HDACsII alpha
2009
Changes in Neurocognitive Function in Patients With Schizophrenia After Starting or Switching to Amisulpride in Comparison With the Normal Controls
Ahn Y, Lee K, Kim C, Kim J, Kang D, Jun T, Choi J, Chung I, Kim H, Hwang S, Kim Y. Changes in Neurocognitive Function in Patients With Schizophrenia After Starting or Switching to Amisulpride in Comparison With the Normal Controls. Journal Of Clinical Psychopharmacology 2009, 29: 117-123. PMID: 19512972, DOI: 10.1097/jcp.0b013e31819a6995.Peer-Reviewed Original ResearchConceptsNormal controlsNeurocognitive functionPP analysisControl groupSecond-generation antipsychoticsEffect sizeHealthy control groupNeurocognitive function testsLong-term improvementComposite effect sizeFunction testsPatient groupMedication effectsTrail Making TestPatientsCognitive improvementPractice effectsSchizophreniaTest batteryRelative effect sizesITTMost measuresGroupAntipsychoticsAmisulpride
2006
Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat
Kim Y, Hong S, Noh M, Kim S, Huh P, Park S, Sun W, Kim H. Induction of Neuron-derived Orphan Receptor-1 in the Dentate Gyrus of the Hippocampal Formation Following Transient Global Ischemia in the Rat. Molecules And Cells 2006, 22: 8-12. PMID: 16951544, DOI: 10.1016/s1016-8478(23)17384-5.Peer-Reviewed Original ResearchConceptsTransient global ischemiaDentate gyrusGlobal ischemiaCultured cerebral cortical neuronsNOR-1Induction of neuronsCerebral cortical neuronsOxygen-glucose deprivationTransient ischemic injuryAdult rat brainForebrain neuronal cellsOrphan receptor 1Different brain regionsBrain ischemiaIschemic injuryCortical neuronsNeuronal depolarizationRat brainHippocampal formationReceptor 1Brain regionsSteroid receptorsIschemiaNeuronal cellsBasal levels