The Evolving Landscape of HER2 Targeting in Breast Cancer
Moasser MM, Krop IE. The Evolving Landscape of HER2 Targeting in Breast Cancer. JAMA Oncology 2015, 1: 1154. PMID: 26204261, DOI: 10.1001/jamaoncol.2015.2286.Peer-Reviewed Original ResearchConceptsTreatment of HER2Breast cancerImmunologic effectorsHER2 targetingSubstantial single-agent activityHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Value of HER2Lines of therapyGrowth factor receptor 2Single-agent activityLate-stage diseaseStage of diseaseUseful predictive biomarkerHER2 inhibitor lapatinibFactor receptor 2Variety of cytotoxicModest efficacyTrastuzumab resistancePredictive biomarkersCell surface expressionImmunologic activityInhibitor lapatinibReceptor 2Advanced stagePersonalization of loco-regional care for primary breast cancer patients (part 1)
Toi M, Winer EP, Benson JR, Inamoto T, Forbes JF, von Minckwitz G, Robertson J, Grobmyer SR, Jatoi I, Sasano H, Kunkler I, Ho AY, Yamauchi C, Chow L, Huang CS, Han W, Noguchi S, Pegram MD, Yamauchi H, Lee ES, Larionov AA, Bevilacqua J, Yoshimura M, Sugie T, Yamauchi A, Krop IE, Noh DY, Klimberg VS. Personalization of loco-regional care for primary breast cancer patients (part 1). Future Oncology 2015, 11: 1297-1300. PMID: 25952777, DOI: 10.2217/fon.15.65.Peer-Reviewed Original ResearchConceptsPrimary systemic therapySystemic therapyConsensus conferenceCompletion axillary lymph node dissectionAxillary lymph node dissectionPrimary breast cancer patientsLoco-regional managementPost-Z0011 eraPreoperative hormonal therapyPrimary surgical patientsLymph node dissectionBreast cancer carePathological tumor stageBreast cancer patientsLoco-regional treatmentPrimary treatment planBreast cancer susceptibilityAxillary irradiationAxillary managementAxillary treatmentNodal depositsAxillary stagingHormonal therapyNode dissectionSentinel lymphPersonalization of loco-regional care for primary breast cancer patients (part 2)
Toi M, Winer EP, Benson JR, Inamoto T, Forbes JF, von Minckwitz G, Robertson J, Grobmyer SR, Jatoi I, Sasano H, Kunkler I, Ho AY, Yamauchi C, Chow L, Huang CS, Han W, Noguchi S, Pegram MD, Yamauchi H, Lee ES, Larionov AA, Bevilacqua J, Yoshimura M, Sugie T, Yamauchi A, Krop IE, Noh DY, Klimberg VS. Personalization of loco-regional care for primary breast cancer patients (part 2). Future Oncology 2015, 11: 1301-1305. PMID: 25952778, DOI: 10.2217/fon.15.66.Peer-Reviewed Original ResearchConceptsPrimary systemic therapyPreoperative hormonal therapySystemic therapyHormonal therapyBreast cancerGenetic predispositionConsensus conferencePrimary breast cancer patientsAdverse pathological factorsDownstaging of tumorsLoco-regional managementNode-positive patientsRegional nodal irradiationBreast cancer careContralateral prophylactic mastectomyPathological tumor stageBreast cancer patientsLoco-regional treatmentSporadic breast cancerBreast cancer susceptibilityAxillary treatmentNodal irradiationAxillary stagingPremenopausal womenClinical response