2023
Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US
Kc M, Fan J, Hyslop T, Hassan S, Cecchini M, Wang S, Silber A, Leapman M, Leeds I, Wheeler S, Spees L, Gross C, Lustberg M, Greenup R, Justice A, Oeffinger K, Dinan M. Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US. JAMA Network Open 2023, 6: e2323115. PMID: 37436746, PMCID: PMC10339147, DOI: 10.1001/jamanetworkopen.2023.23115.Peer-Reviewed Original ResearchConceptsLong-term survivorsCancer-specific mortalityColorectal cancerCancer cohortReceptor statusInitial diagnosisGleason scoreProstate cancerBreast cancerLong-term adult survivorsMedian cancer-specific survivalEnd Results cancer registryProstate-specific antigen levelRectal cancer cohortCancer-specific survivalStage III diseaseYear of diagnosisProgesterone receptor statusEstrogen receptor statusProportion of deathsSurvival time ratioEarly-stage cancerNononcologic outcomesIndex cancerLocalized disease
2022
Do Cultures From Percutaneously Drained Intra-abdominal Abscesses Change Treatment? A Retrospective Review
Esposito A, Zhang Y, Nagarkatti N, Laird W, Coppersmith N, Reddy V, Leeds I, Mongiu A, Longo W, Hao R, Pantel H. Do Cultures From Percutaneously Drained Intra-abdominal Abscesses Change Treatment? A Retrospective Review. Diseases Of The Colon & Rectum 2022, 66: 451-457. PMID: 36538708, DOI: 10.1097/dcr.0000000000002644.Peer-Reviewed Original ResearchConceptsIntra-abdominal abscessPercutaneous drainAntimicrobial therapyLos pacientesAbdominal abscessSingle university-affiliated institutionRetrospective medical record reviewEmpiric antibiotic regimensSolid organ transplantsMedical record reviewUniversity-affiliated institutionCulture dataAntibiotic coursesAbdominal infectionAntibiotic regimensActive smokersMedian ageActive chemotherapyRecord reviewEvidence-based practiceMedian lengthUtility of cultureFemale sexIntraoperative culturesInclusion criteria
2019
Delay in emergency hernia surgery is associated with worse outcomes
Leeds IL, Jones C, DiBrito SR, Sakran JV, Haut ER, Kent AJ. Delay in emergency hernia surgery is associated with worse outcomes. Surgical Endoscopy 2019, 34: 4562-4573. PMID: 31741158, PMCID: PMC8710144, DOI: 10.1007/s00464-019-07245-4.Peer-Reviewed Original ResearchConceptsEmergent surgeryMajor complicationsTiming of surgeryUrgent surgical interventionDay of surgeryLonger operative timeMultivariable logistic regressionEmergency hernia surgeryNext-day surgeryPhysiologic optimizationPostoperative lengthUrgent surgeryMajor morbidityNSQIP databaseOperative timeSurgical timingSurgical outcomesSurgical interventionDiaphragmatic herniaMedical clearanceMultinomial propensity scoresHernia typeWorse outcomesAbdominal herniaHernia surgeryEarly Discontinuation of Infliximab in Pregnant Women With Inflammatory Bowel Disease
Truta B, Leeds IL, Canner JK, Efron JE, Fang SH, Althumari A, Safar B. Early Discontinuation of Infliximab in Pregnant Women With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2019, 26: 1110-1117. PMID: 31670762, DOI: 10.1093/ibd/izz250.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIFX groupDisease activityIFX discontinuationSteroid prescriptionEarly discontinuationPregnancy outcomesPreterm babiesBowel diseaseRisk babiesPregnant womenTruven Health Analytics MarketScan databaseContinuation of infliximabMore preterm babiesAcute respiratory infectionsPoor pregnancy outcomesIntrauterine growth retardationRisk of diseaseDisease flareIBD mothersIBD patientsFetal exposureHospital admissionRespiratory infectionsMarketScan databaseDoes Perceived Resident Operative Autonomy Impact Patient Outcomes?
Fieber JH, Bailey EA, Wirtalla C, Johnson AP, Leeds IL, Medbery RL, Ahuja V, VanderMeer T, Wick EC, Irojah B, Kelz RR. Does Perceived Resident Operative Autonomy Impact Patient Outcomes? Journal Of Surgical Education 2019, 76: e182-e188. PMID: 31377204, DOI: 10.1016/j.jsurg.2019.06.006.Peer-Reviewed Original ResearchConceptsGeneral surgery training programsColorectal resectionSurgery serviceSurgery training programsPatient outcomesTrainee autonomyProspective multi-institutional studyColorectal surgery serviceOpen partial colectomyPrior abdominal surgeryRate of readmissionPatients' clinical outcomesPost-graduate year 3Multi-institutional studyImpact patient outcomesMixed effects regression modelsLower ratesAnesthesiologists classificationSeparate mixed-effects regression modelsColorectal surgeryPrimary outcomeSecondary outcomesAbdominal surgerySerious morbidityClinical outcomes
2018
Eye of the beholder: Risk calculators and barriers to adoption in surgical trainees
Leeds IL, Rosenblum AJ, Wise PE, Watkins AC, Goldblatt MI, Haut ER, Efron JE, Johnston FM. Eye of the beholder: Risk calculators and barriers to adoption in surgical trainees. Surgery 2018, 164: 1117-1123. PMID: 30149939, PMCID: PMC8383120, DOI: 10.1016/j.surg.2018.07.002.Peer-Reviewed Original ResearchConceptsRisk calculatorRisk assessment toolSurgical traineesCurrent risk calculatorsClinical workflow integrationPrimary outcomeMultivariable regressionDomain scoresRoutine useDirect verbal communicationSurgical residentsAccurate risk assessmentBehavioral factorsSystem usability scoreAssessment tool
2017
Quantification of Resident Work in Colorectal Surgery
Bailey EA, Johnson AP, Leeds IL, Medbery RL, Ahuja V, VanderMeer T, Wick EC, Irojah B, Kelz RR. Quantification of Resident Work in Colorectal Surgery. Journal Of Surgical Education 2017, 75: 564-572. PMID: 28986275, DOI: 10.1016/j.jsurg.2017.09.001.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultClinical CompetenceColorectal SurgeryEducation, Medical, GraduateFemaleHumansInternship and ResidencyInterprofessional RelationsLogistic ModelsMaleMultivariate AnalysisOperating RoomsProfessional AutonomyProspective StudiesSurveys and QuestionnairesUnited StatesConceptsSurgery serviceProspective multi-institutional studyColorectal surgery serviceDay of surgeryGeneral surgery serviceGeneral surgery residency programsMulti-institutional studyAcademic medical centerColorectal resectionColorectal surgerySurgery residency programsFascial closureSkin closureMedical CenterSurvey toolNovel survey toolResponse rateIndependent training programsOperating roomStudy periodSurgeonsSurgeryResidency programsDegree of involvementResidents' workEarly Surgical Intervention for Acute Ulcerative Colitis Is Associated with Improved Postoperative Outcomes
Leeds IL, Truta B, Parian AM, Chen SY, Efron JE, Gearhart SL, Safar B, Fang SH. Early Surgical Intervention for Acute Ulcerative Colitis Is Associated with Improved Postoperative Outcomes. Journal Of Gastrointestinal Surgery 2017, 21: 1675-1682. PMID: 28819916, PMCID: PMC6201293, DOI: 10.1007/s11605-017-3538-3.Peer-Reviewed Original ResearchConceptsAcute ulcerative colitisEarly surgical interventionUlcerative colitisLength of staySurgical interventionSurgery groupTotal colectomyHospitalization costsEarly operationMedian total hospitalization costModern immunotherapy eraRefractory ulcerative colitisHours of admissionImmediate surgical interventionUlcerative colitis patientsTotal hospitalization costsFurther prospective studiesNational Inpatient SampleImmunotherapy eraColitis patientsHospital outcomesPostoperative complicationsPostoperative outcomesUrgent surgeryComorbid patientsGracilis Flap for Perineal Closures in Minimally Invasive Abdominoperineal Resection
Leeds IL, Taylor JP, Pozo M, Safar B, Sacks JM, Fang SH. Gracilis Flap for Perineal Closures in Minimally Invasive Abdominoperineal Resection. The American Surgeon 2017, 83: 194-196. PMID: 28637543, DOI: 10.1177/000313481708300606.Peer-Reviewed Original Research
2016
Discharge decision-making after complex surgery: Surgeon behaviors compared to predictive modeling to reduce surgical readmissions
Leeds IL, Sadiraj V, Cox JC, Gao XS, Pawlik TM, Schnier KE, Sweeney JF. Discharge decision-making after complex surgery: Surgeon behaviors compared to predictive modeling to reduce surgical readmissions. The American Journal Of Surgery 2016, 213: 112-119. PMID: 28029373, PMCID: PMC5362294, DOI: 10.1016/j.amjsurg.2016.03.010.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedAged, 80 and overAlgorithmsAttitude of Health PersonnelCohort StudiesDatabases, FactualDecision Making, Computer-AssistedDecision Support TechniquesFemaleHumansIncidenceLogistic ModelsMaleMiddle AgedPatient ReadmissionPredictive Value of TestsRetrospective StudiesRisk AssessmentSurgeonsSurgical Procedures, OperativeTertiary Care CentersUnited StatesYoung AdultOutcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review
Leeds IL, Alturki H, Canner JK, Schneider EB, Efron JE, Wick EC, Gearhart SL, Safar B, Fang SH. Outcomes of abdominoperineal resection for management of anal cancer in HIV-positive patients: a national case review. World Journal Of Surgical Oncology 2016, 14: 208. PMID: 27495294, PMCID: PMC4974747, DOI: 10.1186/s12957-016-0970-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAdultAge FactorsAgedAnus NeoplasmsCarcinoma, Squamous CellComorbidityFemaleFollow-Up StudiesHealth Status DisparitiesHIV InfectionsHospital MortalityHumansIncidenceLength of StayMaleMiddle AgedNeoplasm Recurrence, LocalPerineumPostoperative ComplicationsRetrospective StudiesRisk FactorsSalvage TherapyTreatment OutcomeConceptsHIV-positive patientsLength of stayHIV-negative patientsAnal cancerNational Inpatient SampleAbdominoperineal resectionHospitalization costsHIV infectionAnal squamous cell cancerAnal squamous cell carcinomaUtilization Project National Inpatient SampleGreater hospitalization costsWorse postoperative recoveryHIV-positive groupMethodsA retrospective reviewAnal cancer patientsSquamous cell cancerHuman immunodeficiency virusMultivariable logistic regressionSquamous cell carcinomaHospital mortalityHospital stayPerioperative complicationsPostoperative hemorrhagePostoperative outcomes
2015
Patient Symptomatology in Anal Dysplasia
Hicks CW, Wick EC, Leeds IL, Efron JE, Gearhart SL, Safar B, Fang SH. Patient Symptomatology in Anal Dysplasia. JAMA Surgery 2015, 150: 563-569. PMID: 25874644, DOI: 10.1001/jamasurg.2015.28.Peer-Reviewed Original ResearchConceptsLow-grade dysplasiaAnal dysplasiaHigh-grade dysplasiaAnal painAnal lesionsMultivariable analysisPatient symptomatologyHigh-grade anal dysplasiaHigh-risk patientsMajority of patientsPhysical examination findingsHigh-risk factorsAnal PapanicolaouInitial presentationExamination findingsHIV statusPatient's symptomsPhysical examinationMedical historyBiopsy specimensSilent diseaseRoutine screeningMAIN OUTCOMEHigh riskPatients
2013
Assessing clinical discharge data preferences among practicing surgeons
Leeds IL, Sadiraj V, Cox JC, Schnier KE, Sweeney JF. Assessing clinical discharge data preferences among practicing surgeons. Journal Of Surgical Research 2013, 184: 42-48.e3. PMID: 23706559, PMCID: PMC3758431, DOI: 10.1016/j.jss.2013.03.064.Peer-Reviewed Original ResearchInternational surgical clerkship rotation: perceptions and academic performance
Leeds IL, Hugar LA, Pettitt BJ, Srinivasan J, Master VA. International surgical clerkship rotation: perceptions and academic performance. The American Journal Of Surgery 2013, 206: 280-286. PMID: 23481029, DOI: 10.1016/j.amjsurg.2012.10.034.Peer-Reviewed Original ResearchConceptsAcademic performanceSurgical clerkshipThird-year surgical clerkshipMixed-methods web-based surveyMedical school curriculumInternational training experiencesAcademic year 2008Unique clinical experienceGlobal health experiencesStudent learningSchool curriculumClinical curriculumNonparticipating peersM3 studentsEducational effectsLeadership skillsClinical trainingStudentsAppropriate clinical trainingInternational electivesCultural competencySurgical electivesElectiveTraining experienceCurriculum
2012
Risk Factors for 30-Day Hospital Readmission among General Surgery Patients
Kassin MT, Owen RM, Perez SD, Leeds I, Cox JC, Schnier K, Sadiraj V, Sweeney JF. Risk Factors for 30-Day Hospital Readmission among General Surgery Patients. Journal Of The American College Of Surgeons 2012, 215: 322-330. PMID: 22726893, PMCID: PMC3423490, DOI: 10.1016/j.jamcollsurg.2012.05.024.Peer-Reviewed Original ResearchConceptsGeneral surgery proceduresGeneral surgery patientsRisk of readmissionPostoperative complicationsRisk factorsSurgery proceduresSurgery patientsHospital readmissionInpatient general surgery proceduresInstitutional clinical data warehousePoor quality patient careSignificant independent risk factorsPreoperative open woundSepsis/shockPostoperative pulmonary complicationsDays of dischargeIndependent risk factorUrinary tract infectionSingle academic centerType of procedureClinical data warehousePostoperative readmissionsPulmonary complicationsIndex hospitalizationPostoperative occurrence
2011
Learning from Haiti
Creighton FX, Leeds IL, Master VA, Srinivasan JK. Learning from Haiti. The Lancet 2011, 377: 2054. PMID: 21665039, DOI: 10.1016/s0140-6736(11)60409-1.Peer-Reviewed Original Research