EFEMP1 as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling
Kim Y, Yoon H, Kim S, Kim Y, Kim E, Kim I, Kim W. EFEMP1 as a Novel DNA Methylation Marker for Prostate Cancer: Array-Based DNA Methylation and Expression Profiling. Clinical Cancer Research 2011, 17: 4523-4530. PMID: 21571867, DOI: 10.1158/1078-0432.ccr-10-2817.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAzacitidineBiomarkers, TumorCell Line, TumorCpG IslandsDecitabineDNA MethylationDNA Modification MethylasesEpigenomicsExtracellular Matrix ProteinsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPromoter Regions, GeneticProstatic HyperplasiaProstatic NeoplasmsReproducibility of ResultsConceptsEpidermal growth factor-containing fibulin-like extracellular matrix protein 1DNA methylationGene Expression OmnibusExpression profilingProstate cell linesGenome-wide characterizationCell linesMethylation statusExtracellular matrix protein 1Methylation markersDNA methylation profilesBisulfite sequencing analysisFibulin-like extracellular matrix protein 1Aberrant methylation patternsAbnormal DNA methylationExpression levelsNovel methylation markersGene expression analysisGene expression profilingNovel DNA methylation markersMatrix protein 1Gene expression dataGene expression levelsMicroarray gene expression dataMethylation patternsA Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer
Kim W, Kim S, Jeong P, Yun S, Cho I, Kim I, Moon S, Um H, Choi Y. A Four-Gene Signature Predicts Disease Progression in Muscle Invasive Bladder Cancer. Molecular Medicine 2011, 17: 478-485. PMID: 21308147, PMCID: PMC3105150, DOI: 10.2119/molmed.2010.00274.Peer-Reviewed Original ResearchConceptsMuscle-invasive bladder cancerFour-gene signatureInvasive bladder cancerDisease progressionMIBC patientsMIBC progressionBladder cancerIndependent cohortMultivariate Cox regression analysisCox regression analysisReal-time reverse transcriptase-polymerase chain reactionReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionGene expression signaturesIndependent predictorsPatient survivalPrognostic valuePromising diagnostic toolPolymerase chain reactionHigh riskPredictive valueMicroarray gene expression profilingImportant mediatorPatientsGene expression profiling