2016
Patient stem cell (SC)-derived prostate cancer (PC) organoids (Org) to recreate clonal heterogeneity of PC foci and measure therapeutic response potential.
Ferrari A, DiPaola R, Bertino J, Kim I, Stein M, Sabaawy H, Bartucci M. Patient stem cell (SC)-derived prostate cancer (PC) organoids (Org) to recreate clonal heterogeneity of PC foci and measure therapeutic response potential. Journal Of Clinical Oncology 2016, 34: 252-252. DOI: 10.1200/jco.2016.34.2_suppl.252.Peer-Reviewed Original ResearchResidual tumor fociMesenchymal growth factorsRadical prostatectomy specimensClonal heterogeneityTumor initiating cellsProstate cancer organoidsMechanisms of resistanceMetastatic PCPC progressionTherapeutic alternativeTumor fociNormal epitheliumPatient stem cellsProstatectomy specimensMolecular alterationsPotential efficacyCancer organoidsSelf-renewal capacityInitiating cellsGrowth factorBiologic responseEarly passagesGrowth inhibitionStem cellsEpigenetic alterations
1998
Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1
Rohlff C, Blagosklonny M, Kyle E, Kesari A, Kim I, Zelner D, Hakim F, Trepel J, Bergan R. Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1. The Prostate 1998, 37: 51-59. PMID: 9721069, DOI: 10.1002/(sici)1097-0045(19980915)37:1<51::aid-pros8>3.0.co;2-b.Peer-Reviewed Original ResearchConceptsProstate cancer cell growthCancer cell growthProtein kinase CHormone-refractory prostate cancerProstate cancer cell growth inhibitionGrowth inhibitionInhibition of PKCG1/S phase cell cycle arrestTamoxifen-mediated growth inhibitionCancer cell growth inhibitionProstate cancer cellsPhase cell cycle arrestDU145 prostate cancer cellsS-phase cell cycle arrestRetinoblastoma protein levelsFlow cytometric analysisP21WAF1/CIP1Cell growth inhibitionTamoxifen treatmentCell cycle arrestCell growthProstate cancerKinase CCytometric analysisWestern blot