2013
BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Lee J, Lee G, Woo S, Ha Y, Kwon S, Kim W, Kim I. BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages. Cancer Research 2013, 73: 3604-3614. PMID: 23633487, DOI: 10.1158/0008-5472.can-12-4563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Carcinoma, Renal CellCell LineCell Line, TumorCell ProliferationClodronic AcidDoxycyclineHumansImmunoblottingInterleukin-10Kaplan-Meier EstimateKidney NeoplasmsMacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, FluorescenceReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSmad5 ProteinSTAT3 Transcription FactorTumor Burden
2010
Bone Morphogenetic Protein Signaling: Implications in Urology
Jeong J, Kang D, Lee G, Kim I. Bone Morphogenetic Protein Signaling: Implications in Urology. Investigative And Clinical Urology 2010, 51: 511-517. PMID: 20733955, PMCID: PMC2924553, DOI: 10.4111/kju.2010.51.8.511.Peer-Reviewed Original ResearchBone morphogenetic proteinSmall molecule inhibitorsBMP signalingTransmembrane serine/threonine kinase receptorsSerine/threonine kinase receptorsSubsequent signal transduction cascadesMolecule inhibitorsFirst small-molecule inhibitorSignal transduction cascadeMultiple key stepsSmad-independent pathwaysDiverse human diseasesHeteromeric complexesTransduction cascadeEmbryonic developmentInhibitory SmadsMorphogenetic proteinsReceptor domainHuman diseasesKinase receptorsCritical functionsPathwayCritical roleNovel therapeuticsSignaling
2009
Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages
Kwon S, Lee G, Lee J, Kim W, Kim I. Bone morphogenetic protein‐6 induces the expression of inducible nitric oxide synthase in macrophages. Immunology 2009, 128: e758-e765. PMID: 19740337, PMCID: PMC2753926, DOI: 10.1111/j.1365-2567.2009.03079.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingBone Morphogenetic Protein 6Cells, CulturedCycloheximideDactinomycinHumansInterleukin-1betaMacrophages, PeritonealMiceNF-kappa BNitric Oxide Synthase Type IIProtein Synthesis InhibitorsRecombinant ProteinsSignal TransductionSmad ProteinsTumor Necrosis Factor-alphaConceptsBone morphogenetic proteinBMP-6Effects of BMPBone morphogenetic protein 6New protein synthesisMorphogenetic proteinsMurine macrophage cell lineMacrophage cell lineImportant regulatorProtein synthesisProtein 6Cell typesMouse peritoneal macrophagesCell linesActinomycin DNF-kappaBSmadExpressionDose-dependent mannerSynthaseNitric oxide synthasePathwayInductionInducible nitric oxide synthasePeritoneal macrophages
2007
Expression of Bone Morphogenetic Proteins, the Subfamily of the Transforming Growth Factor-β Superfamily, in Renal Cell Carcinoma
Kwak C, Park Y, Kim I, Moon K, Ku J. Expression of Bone Morphogenetic Proteins, the Subfamily of the Transforming Growth Factor-β Superfamily, in Renal Cell Carcinoma. Journal Of Urology 2007, 178: 1062-1067. PMID: 17644140, DOI: 10.1016/j.juro.2007.05.005.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinBone morphogenetic protein 4Morphogenetic proteinsBone morphogenetic protein-7 expressionGrowth factor β superfamilyProtein-7 expressionTransforming Growth Factor-β SuperfamilyBone morphogenetic protein-4 expressionBone morphogenetic protein expressionProtein 4Largest subfamilyProtein expression rateCell typesProtein 4 expressionProteinProtein expressionSubfamiliesRenal cell carcinomaExpressionExpression rateSuperfamilyClear cell typePotential expressionCell carcinomaProtein immunoreactivity
2006
Role of bone morphogenetic proteins in transitional cell carcinoma cells
Kim I, Kim S. Role of bone morphogenetic proteins in transitional cell carcinoma cells. Cancer Letters 2006, 241: 118-123. PMID: 16500023, DOI: 10.1016/j.canlet.2005.10.009.Peer-Reviewed Original Research
2004
Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells
Kim I, Lee D, Lee D, Ahn H, Kim M, Kim S, Morton R. Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells. Oncogene 2004, 23: 7651-7659. PMID: 15354178, DOI: 10.1038/sj.onc.1207924.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinProstate cancer cellsHuman prostate cancer cellsLoss of expressionProstate cancer patientsBMP-RIICancer patientsGleason scoreBMP receptor type IABone morphogenetic protein receptor type IICancer cellsSignificant associationHuman prostate cancer cell linesBiochemical recurrence-free rateExpression of BMPRsRecurrence-free rateProstate cancer cell linesCell linesTumor growth rateReceptor type IIParental cell lineCancer cell linesMorphogenetic proteinsClinical stagePrognostic value