2016
BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer
Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon Y, Zhong H, Medina D, Kerrigan J, Stein M, Kim I, Davis T, DiPaola R, Bertino J, Sabaawy H. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clinical Cancer Research 2016, 22: 6176-6191. PMID: 27307599, PMCID: PMC5159329, DOI: 10.1158/1078-0432.ccr-15-3107.Peer-Reviewed Original ResearchConceptsTumor-initiating cellsProstate tumor-initiating cellsBmi-1Androgen receptor-directed therapyIntrinsic therapy resistanceReceptor-directed therapyProstate cancer managementProstate cancer treatmentMore effective therapiesBmi-1 expressionProstate cancer cellsStem cell-like traitsSelf-renewing tumor-initiating cellsCell-like traitsPatient-derived cellsEffective therapyTumor relapseCancer managementXenograft modelTherapy resistancePharmacologic inhibitionBmi-1 functionTherapyNormal tissuesCancer treatment
1998
Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes.
Lee D, Yang S, Hong S, Chung B, Kim I. Telomerase: a potential marker of bladder transitional cell carcinoma in bladder washes. Clinical Cancer Research 1998, 4: 535-8. PMID: 9533519.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaBladder transitional cell carcinomaBladder washesCell carcinomaCytological diagnosisTelomerase activityGrade 1 transitional cell carcinomaCancer tissuesNormal tissuesHuman bladder cancer tissuesBladder wash samplesPositive telomerase activityFinal pathological diagnosisLow-grade tumorsBladder cancer tissuesTelomeric repeat amplificationPositive cytologyTransurethral resectionBladder tumorsBladder cancerPathological diagnosisWash samplesCytological specimensPatientsPotential marker
1997
Telomerase activity: a potential marker of bladder transitional cell carcinoma in bladder washes
Yang S, Lee D, Hong S, Chung B, Kim I. Telomerase activity: a potential marker of bladder transitional cell carcinoma in bladder washes. Yonsei Medical Journal 1997, 38: 155-159. PMID: 9259615, DOI: 10.3349/ymj.1997.38.3.155.Peer-Reviewed Original ResearchConceptsTransitional cell carcinomaTelomeric repeat amplification protocolWash specimensBladder cancerBladder wash specimensCancer tissuesCell carcinomaCytologic diagnosisTelomerase activityCytopathologic diagnosisGrade 1 transitional cell carcinomaNormal tissuesBladder transitional cell carcinomaHuman bladder cancer tissuesBladder wash cytologyFinal pathologic diagnosisBladder cancer tissuesRepeat amplification protocolPolymerase chain reaction techniqueTransurethral resectionChain reaction techniquePathologic diagnosisBladder washesSame patientGrade 2