2021
Factors Associated with Palliative Care (PC) Utilization in Advanced and Metastatic Renal Cell Carcinoma (RCC)
Patel H, Sterling J, Srivastava A, Saraiya B, Mayer T, Kim I, Ghodoussipour S, Jang T, Singer E. Factors Associated with Palliative Care (PC) Utilization in Advanced and Metastatic Renal Cell Carcinoma (RCC). Journal Of The American College Of Surgeons 2021, 233: e230-e231. DOI: 10.1016/j.jamcollsurg.2021.08.623.Peer-Reviewed Original ResearchFactors associated with palliative care utilization in advanced and metastatic renal cell carcinoma.
Patel H, Sterling J, Srivastava A, Kim S, Saraiya B, Mayer T, Kim I, Ghodoussipour S, Jang T, Singer E. Factors associated with palliative care utilization in advanced and metastatic renal cell carcinoma. Journal Of Clinical Oncology 2021, 39: 146-146. DOI: 10.1200/jco.2020.39.28_suppl.146.Peer-Reviewed Original ResearchAdvanced renal cell carcinomaRenal cell carcinomaStage IV renal cell carcinomaPalliative care utilizationNational Cancer DatabasePalliative careClinical factorsCare utilizationCell carcinomaStage IIITreatment-specific mannerStage III renal cell carcinomaPC utilizationMetastatic renal cell carcinomaPalliative care useDisease-specific symptomsMultivariable logistic regressionComprehensive cancer programsQuality of lifeOncological guidelinesSarcomatoid histologyAdvanced malignanciesOverall cohortHigher education statusMultivariable analysis
2019
DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome
Na J, Nagaya N, Rha K, Han W, Kim I. DNA Damage Response Pathway Alteration in Locally Advanced Clear-Cell Renal-Cell Carcinoma Is Associated With a Poor Outcome. Clinical Genitourinary Cancer 2019, 17: 299-305.e1. PMID: 31204211, DOI: 10.1016/j.clgc.2019.05.004.Peer-Reviewed Original ResearchConceptsClear cell renal cell carcinomaDisease-free survivalAdvanced clear cell renal cell carcinomaDDR pathway alterationPathway alterationsLocalized Clear Cell Renal Cell CarcinomaDecreased disease-free survivalTCGA databaseShorter disease-free survivalCopy number alterationsTherapeutic agentsCox regression analysisT3-4 diseaseClear-Cell RenalRenal cell carcinomaDDR pathwaysPresence of mutationsT3a diseaseNeoadjuvant therapyOverall survivalPoor outcomeCell carcinomaCommon subtypeDisease progressionKidney cancerMP14-20 IMPACT OF PATHOLOGIC NODE POSITIVE RENAL CELL CARCINOMA ON SURVIVAL IN PATIENTS WITHOUT METASTASIS: EVIDENCE IN SUPPORT OF EXPANDING THE DEFINITION OF STAGE IV KIDNEY CANCER
Srivastava* A, Rivera-Nunez Z, Kim S, Sterling J, Farber N, Radadia K, Modi P, Goyal S, Parikh R, Mayer T, Saraiya B, Weiss R, Kim I, Elsamra S, Jang T, Singer E. MP14-20 IMPACT OF PATHOLOGIC NODE POSITIVE RENAL CELL CARCINOMA ON SURVIVAL IN PATIENTS WITHOUT METASTASIS: EVIDENCE IN SUPPORT OF EXPANDING THE DEFINITION OF STAGE IV KIDNEY CANCER. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000555316.15591.47.Peer-Reviewed Original ResearchTreatment disparities among patients in the National Cancer Database (NCDB) with clinical TIa and TIb renal masses.
Sterling J, Rivera-Nunez Z, Farber N, Modi P, Radadia K, Kim S, Sharad G, Rahul P, Weiss R, Kim I, Elsamra S, Jang T, Singer E. Treatment disparities among patients in the National Cancer Database (NCDB) with clinical TIa and TIb renal masses. Journal Of Clinical Oncology 2019, 37: 648-648. DOI: 10.1200/jco.2019.37.7_suppl.648.Peer-Reviewed Original ResearchRenal cell carcinomaNational Cancer DatabaseCT1b patientsPartial nephrectomyCT1a patientsOpen procedureAcademic centersCT1 renal cell carcinomaUtilization of PNPrivate insuranceClinical T1a tumorsPatterns of careLower household incomeLogistic regression modelsCT1a tumorsCT1b tumorsRCC surgeryT1a tumorsClinical characteristicsCT1 tumorsT1b tumorsTreatment disparitiesImpact of regionalizationCell carcinomaAUA guidelinesFactors linked with receiving a lymph node dissection during surgery for nonmetastatic renal cell carcinoma.
Radadia K, Rivera-Nunez Z, Kim S, Farber N, Sterling J, Modi P, Sharad G, Rahul P, Weiss R, Kim I, Elsamra S, Jang T, Singer E. Factors linked with receiving a lymph node dissection during surgery for nonmetastatic renal cell carcinoma. Journal Of Clinical Oncology 2019, 37: 672-672. DOI: 10.1200/jco.2019.37.7_suppl.672.Peer-Reviewed Original ResearchClinical lymph nodesLymph node dissectionRenal cell carcinomaNational Cancer DatabaseTime of surgeryNode dissectionCell carcinomaTreatment centersPositive clinical lymph nodesNonmetastatic renal cell carcinomaAmerican Urological Association guidelinesNon-metastatic patientsClinical T stageEntire study populationPreoperative imaging modalitiesLogistic regression modelsGreatest predictorClinical characteristicsNodal involvementClinical stagingLymph nodesRegional lymphadenopathyT stageOpen surgeryRenal surgery
2018
Role of the androgen signaling axis in genitourinary malignancies.
Shinder B, Shupe A, Lee G, Stein M, Kim I, Singer E. Role of the androgen signaling axis in genitourinary malignancies. Translational Cancer Research 2018, 7: 1135-1142. PMID: 30701159, PMCID: PMC6349041, DOI: 10.21037/tcr.2018.03.41.Peer-Reviewed Original ResearchRenal cell carcinomaGenitourinary malignanciesAndrogen receptorBladder cancerRole of ARAdvanced disease stateProstate cancer developmentNovel therapeutic strategiesCell carcinomaTherapeutic armamentariumTherapeutic strategiesMortality rateCancer developmentMalignancyAndrogensDisease statesCancerCarcinomaProstateArmamentariumMolecular biologyDiseaseProgressionRoleReceptors
2017
Intracrine androgen biosynthesis in renal cell carcinoma
Lee G, Han C, Kwon Y, Patel R, Modi P, Kwon S, Faiena I, Patel N, Singer E, Ahn H, Kim W, Kim I. Intracrine androgen biosynthesis in renal cell carcinoma. British Journal Of Cancer 2017, 116: 937-943. PMID: 28253524, PMCID: PMC5379152, DOI: 10.1038/bjc.2017.42.Peer-Reviewed Original ResearchMeSH KeywordsAbiraterone AcetateAndrogensAnimalsAntineoplastic AgentsApoptosisBenzamidesBlotting, WesternCarcinoma, Renal CellCell ProliferationDihydrotestosteroneFemaleHumansImmunoenzyme TechniquesKidney NeoplasmsMaleMiceMice, NudeNitrilesOrchiectomyPhenylthiohydantoinPrognosisProstatic NeoplasmsProstatic Neoplasms, Castration-ResistantReal-Time Polymerase Chain ReactionReceptors, AndrogenReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTestosteroneTumor Cells, CulturedXenograft Model Antitumor AssaysConceptsRenal cell carcinomaCastration-resistant prostate cancerRCC cell linesAnti-androgen therapyHuman RCC cell linesAndrogen biosynthesisAbiraterone acetateCell carcinomaAndrogen receptorTumor volumeCell linesAndrogen deprivation therapyHigher tumor stageProstate cancer patientsMouse xenograft studiesGenitourinary cancersTumor suppressionSignificant tumor suppressionRCC patientsTumor stageCancer patientsMale miceProstate cancerIntratumoral steroidogenesisXenograft studies
2016
MP92-12 ANTI-ANDROGEN THERAPY SUPPRESSES TUMOR GROWTH IN ANDROGEN RECEPTOR-POSITIVE RENAL CELL CARCINOMA: A XENOGRAFT STUDY
Han C, Lee G, Patel R, Modi P, Kwon S, Faiena I, Patel N, Singer E, Kim I. MP92-12 ANTI-ANDROGEN THERAPY SUPPRESSES TUMOR GROWTH IN ANDROGEN RECEPTOR-POSITIVE RENAL CELL CARCINOMA: A XENOGRAFT STUDY. Journal Of Urology 2016, 195: e1166. DOI: 10.1016/j.juro.2016.02.2645.Peer-Reviewed Original Research
2015
MP47-05 ANDROGEN RECEPTOR MRNA EXPRESSION IS ASSOCIATED WITH PROGNOSIS IN LOCALIZED RENAL CELL CARCINOMA
Modi P, Ha Y, Lee G, Ahn H, Kim W, Kim I. MP47-05 ANDROGEN RECEPTOR MRNA EXPRESSION IS ASSOCIATED WITH PROGNOSIS IN LOCALIZED RENAL CELL CARCINOMA. Journal Of Urology 2015, 193: e553-e554. DOI: 10.1016/j.juro.2015.02.1525.Peer-Reviewed Original ResearchIncreased Expression of Androgen Receptor mRNA in Human Renal Cell Carcinoma Cells is Associated with Poor Prognosis in Patients with Localized Renal Cell Carcinoma
Ha Y, Lee G, Modi P, Kwon Y, Ahn H, Kim W, Kim I. Increased Expression of Androgen Receptor mRNA in Human Renal Cell Carcinoma Cells is Associated with Poor Prognosis in Patients with Localized Renal Cell Carcinoma. Journal Of Urology 2015, 194: 1441-1448. PMID: 25796113, DOI: 10.1016/j.juro.2015.03.078.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBlotting, WesternCarcinoma, Renal CellCell Line, TumorDisease ProgressionFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansKidney NeoplasmsMaleMiddle AgedNeoplasm StagingPrognosisReal-Time Polymerase Chain ReactionReceptors, AndrogenRetrospective StudiesRNA, NeoplasmTime FactorsYoung AdultConceptsRenal cell carcinomaAndrogen receptor mRNA expressionReceptor mRNA expression levelsCancer-specific survivalCell carcinomaCell carcinoma cell linesReceptor mRNA expressionHuman renal cell carcinoma cell linesRenal cell carcinoma cell linesAndrogen receptorMRNA expression levelsSpecific survivalCarcinoma cell linesMultivariate Cox regression analysisLocalized Renal Cell CarcinomaMRNA expressionT2 renal cell carcinomaCell linesPathological stage T1Androgen receptor expressionCox regression analysisKaplan-Meier estimatesReceptor-positive cell linesChain reactionPositive renal cell carcinomas
2013
BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages
Lee J, Lee G, Woo S, Ha Y, Kwon S, Kim W, Kim I. BMP-6 in Renal Cell Carcinoma Promotes Tumor Proliferation through IL-10–Dependent M2 Polarization of Tumor-Associated Macrophages. Cancer Research 2013, 73: 3604-3614. PMID: 23633487, DOI: 10.1158/0008-5472.can-12-4563.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Carcinoma, Renal CellCell LineCell Line, TumorCell ProliferationClodronic AcidDoxycyclineHumansImmunoblottingInterleukin-10Kaplan-Meier EstimateKidney NeoplasmsMacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, FluorescenceReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSmad5 ProteinSTAT3 Transcription FactorTumor Burden
2007
Expression of Bone Morphogenetic Proteins, the Subfamily of the Transforming Growth Factor-β Superfamily, in Renal Cell Carcinoma
Kwak C, Park Y, Kim I, Moon K, Ku J. Expression of Bone Morphogenetic Proteins, the Subfamily of the Transforming Growth Factor-β Superfamily, in Renal Cell Carcinoma. Journal Of Urology 2007, 178: 1062-1067. PMID: 17644140, DOI: 10.1016/j.juro.2007.05.005.Peer-Reviewed Original ResearchConceptsBone morphogenetic proteinBone morphogenetic protein 4Morphogenetic proteinsBone morphogenetic protein-7 expressionGrowth factor β superfamilyProtein-7 expressionTransforming Growth Factor-β SuperfamilyBone morphogenetic protein-4 expressionBone morphogenetic protein expressionProtein 4Largest subfamilyProtein expression rateCell typesProtein 4 expressionProteinProtein expressionSubfamiliesRenal cell carcinomaExpressionExpression rateSuperfamilyClear cell typePotential expressionCell carcinomaProtein immunoreactivity
2001
Laparoscopic nephrectomy for renal cell carcinoma
Kim I, Schulam P. Laparoscopic nephrectomy for renal cell carcinoma. Current Urology Reports 2001, 2: 40-45. PMID: 12084294, DOI: 10.1007/s11934-001-0024-x.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCell carcinomaLaparoscopic nephrectomyPerioperative analgesic useBenefits of laparoscopyPort-site metastasisInadequate surgical resectionFull convalescenceAnalgesic usePerioperative morbiditySurgical resectionOperative timeOpen surgeryBetter cosmesisTumor recurrenceLower incidenceClayman et alCarcinomaNephrectomyLaparoscopyPreliminary dataSurgeryLength of time