2020
Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases
Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D, Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs SE, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD, Robin TP. Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases. JAMA Oncology 2020, 6: 1028-1037. PMID: 32496550, PMCID: PMC7273318, DOI: 10.1001/jamaoncol.2020.1271.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain NeoplasmsCranial IrradiationFemaleHumansLung NeoplasmsMaleMiddle AgedRadiosurgeryRetrospective StudiesSmall Cell Lung CarcinomaConceptsWhole brain radiotherapyProgression-free survivalSmall-cell lung cancer (SCLC) brain metastasesCell lung cancer brain metastasesCNS progression-free survivalLung cancer brain metastasesPropensity score-matched analysisMedian overall survivalCancer brain metastasesBrain metastasesOverall survivalStereotactic radiosurgeryCentral nervous system (CNS) progression-free survivalMedian CNS progression-free survivalSRS outcomesCentral nervous system progressionSmall cell lung cancerLimited brain metastasesMulticenter cohort studyDisease control statusCell lung cancerSingle-arm trialStandard of careLeptomeningeal progressionWBRT cohort
2017
Cost-Effectiveness of Thoracic Radiation Therapy for Extensive-Stage Small Cell Lung Cancer Using Evidence From the Chest Radiotherapy Extensive-Stage Small Cell Lung Cancer Trial (CREST)
Patrice G, Lester-Coll N, Yu J, Amdahl J, Delea T, Patrice S. Cost-Effectiveness of Thoracic Radiation Therapy for Extensive-Stage Small Cell Lung Cancer Using Evidence From the Chest Radiotherapy Extensive-Stage Small Cell Lung Cancer Trial (CREST). International Journal Of Radiation Oncology • Biology • Physics 2017, 100: 97-106. PMID: 29029885, DOI: 10.1016/j.ijrobp.2017.08.041.Peer-Reviewed Original ResearchConceptsExtensive-stage small cell lung cancerThoracic radiation therapyProgression-free survivalIncremental cost-effectiveness ratioExtensive-stage small cell lung cancer patientsSmall cell lung cancerCell lung cancerStandard treatmentLung cancer trialsRadiation therapyOverall survivalLung cancerUS health care payer perspectiveLong-term survival benefitCancer trialsFavorable incremental cost-effectiveness ratiosProgressive metastatic diseaseHealth care payer perspectiveProportion of patientsBase-case analysisFollow-up intervalCost-effectiveness ratioMetastatic diseasePostprogression survivalPayer perspective
2014
Decision Analysis of Stereotactic Radiation Surgery Versus Stereotactic Radiation Surgery and Whole-Brain Radiation Therapy for 1 to 3 Brain Metastases
Lester-Coll N, Dosoretz A, Yu J. Decision Analysis of Stereotactic Radiation Surgery Versus Stereotactic Radiation Surgery and Whole-Brain Radiation Therapy for 1 to 3 Brain Metastases. International Journal Of Radiation Oncology • Biology • Physics 2014, 89: 563-568. PMID: 24751412, DOI: 10.1016/j.ijrobp.2014.03.001.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyStereotactic radiation surgeryQuality-adjusted life monthsQuality-adjusted life expectancyAdjuvant whole-brain radiation therapyBrain metastasesRadiation therapyRadiation surgeryPerformance statusOmission of whole-brain radiation therapyCompare quality-adjusted life expectancySalvage whole brain radiation therapySurveillance magnetic resonance imagingSide effectsQuality of lifeMarkov decision analysis modelControl intracranial diseaseIntracranial tumor controlPoor performance statusCohort of patientsNeurocognitive side effectsOne-way sensitivity analysesKarnofsky performance statusIntracranial progressionIntracranial relapse
2011
Hippocampal-Sparing Whole-Brain Radiotherapy: A “How-To” Technique Using Helical Tomotherapy and Linear Accelerator-Based Intensity-Modulated Radiotherapy: In Regard to Gondi V, et al. (Int J Radiat Oncol Biol Phys 2010;78:1244–1252)
Knisely J, Yu J. Hippocampal-Sparing Whole-Brain Radiotherapy: A “How-To” Technique Using Helical Tomotherapy and Linear Accelerator-Based Intensity-Modulated Radiotherapy: In Regard to Gondi V, et al. (Int J Radiat Oncol Biol Phys 2010;78:1244–1252). International Journal Of Radiation Oncology • Biology • Physics 2011, 79: 957-958. PMID: 21281899, DOI: 10.1016/j.ijrobp.2010.11.001.Peer-Reviewed Original Research
2007
A Dosimetric Evaluation of Conventional Helmet Field Irradiation Versus Two-Field Intensity-Modulated Radiotherapy Technique
Yu J, Shiao S, Knisely J. A Dosimetric Evaluation of Conventional Helmet Field Irradiation Versus Two-Field Intensity-Modulated Radiotherapy Technique. International Journal Of Radiation Oncology • Biology • Physics 2007, 68: 621-631. PMID: 17276616, DOI: 10.1016/j.ijrobp.2006.12.004.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsCranial IrradiationHumansRadiographyRadiotherapy DosageRadiotherapy, Intensity-ModulatedConceptsIntensity-modulated radiotherapyDose uniformityCompare dose-volume histogramsIntensity-modulated radiotherapy fieldsIntensity-modulated radiotherapy plansOptimal dose uniformityDose-volume histogramsPlanning target volumeDosimetric differencesDose inhomogeneityDosimetric evaluationField irradiationTarget volumeField anglePrescribed doseLong-term cognitive functionBrain radiotherapyRadiotherapy portalsPercentage of brainRadiotherapy fieldEBRTSpinal cordDosePatientsClinical implications