2023
Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2019
67 Appraisal of Follow-up Protocols and Outcomes of High Risk Pancreatic Cancer Surveillance Programs: A Systematic Review and Meta-Analysis
Chhoda A, Mukherjee E, Wattamwar K, Kastrinos F, Farrell J. 67 Appraisal of Follow-up Protocols and Outcomes of High Risk Pancreatic Cancer Surveillance Programs: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2019, 114: s40-s41. DOI: 10.14309/01.ajg.0000589800.17291.ef.Peer-Reviewed Original ResearchHigh-risk individualsCross-sectional imagingEndoscopic ultrasoundPancreatic cancerDiagnostic rateSectional imagingSystematic reviewPt-yrNew lesionsBaseline imagingAdvanced pathologyCumulative progression rateCancer Surveillance ProgramOptimal imaging modalityPre-existing abnormalitiesSignificant differencesOutcomes of interestRandom-effects modelFirst systematic reviewUncontrolled studiesProspective studySubgroup analysisSurveillance protocolHistologic diagnosisProgression rate