2023
Racial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance.
Klute K, Lucas A, Brand R, Everett J, Farrell J, Hawthorne K, Kaul V, Kupfer S, Paiella S, Simeone D, Sussman D, Zogopoulos G, Kastrinos F, Katona B, Consortium A. Racial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance. Journal Of Clinical Oncology 2023, 41: 687-687. DOI: 10.1200/jco.2023.41.4_suppl.687.Peer-Reviewed Original ResearchHigh-risk individualsSex-based disparitiesFamilial pancreatic cancerPDAC surveillancePancreatic cancer surveillancePeutz-Jeghers syndromeRates of consentSex-based differencesMedian ageAshkenazi Jewish ancestryMulticenter studyProspective studyCancer surveillancePancreatic cancerFamily historyLarge cohortMelanoma syndromeHereditary pancreatitisEarly detection researchStudy participantsEarly detectionStudy periodGermline DNACohortPDACPancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer.
Haimi I, Zogopoulos G, Dettwyler S, Everett J, Bi Y, Brand R, Chung D, Farrell J, Grossberg A, Kastrinos F, Katona B, Klute K, Kupfer S, Lucas A, Paiella S, Parmigiani G, Permuth J, Sears R, Sussman D, Simeone D, Consortium P. Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer. Journal Of Clinical Oncology 2023, 41: 689-689. DOI: 10.1200/jco.2023.41.4_suppl.689.Peer-Reviewed Original ResearchHigh-risk individualsPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCohort 1Worrisome featuresPancreatic cancerMain pancreatic duct diameterSolid massPancreatic duct diameterStandardized image acquisitionPGV groupGermline testingDuct stricturesIncurable stageMultiple cystsPancreatic abnormalitiesStandardized data collection systemNeuroendocrine tumorsDuctal adenocarcinomaCommon abnormalityFamily historyBenign lesionsLethal cancersPDAC risk
2022
The PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer.
Zogopoulos G, Bi Y, Brand R, Chung D, Earl J, Farrell J, Graff J, Kastrinos F, Katona B, Klute K, Koptiuch C, Kupfer S, Kwon R, Lindberg J, Lowy A, Lucas A, Paiella S, Permuth J, Sears R, Simeone D, Consortium T. The PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer. Journal Of Clinical Oncology 2022, 40: e16239-e16239. DOI: 10.1200/jco.2022.40.16_suppl.e16239.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCancer predisposition genesCohort studyPancreatic cancerClinical dataAnnual surveillanceEffective early detection strategiesHigh-quality clinical dataHigh-risk premalignant lesionsModifiers of riskInternational cohort studyProspective cohort studyEarly-stage diseaseOverall survival rateEarly detection strategiesEarly-stage cancerBlood sample collectionRelevant clinical populationContribution of heritabilityPenetrance of diseaseQuality clinical dataParticipants ages 18Germline testing
2019
Updated international Cancer of the Pancreas Screening (CAPS) consortium guidelines on the management of patients with increased risk for familial pancreatic cancer
Overbeek K, Canto M, Bartsch D, Brand R, Carrato A, Del Chiaro M, Farrell J, Fishman E, Fockens P, Gress T, van Hooft J, Kastrinos F, Rustgi A, Syngal S, Vasen H, Cahen D, Bruno M, Goggins M, Consortium I. Updated international Cancer of the Pancreas Screening (CAPS) consortium guidelines on the management of patients with increased risk for familial pancreatic cancer. Pancreatology 2019, 19: s56-s57. DOI: 10.1016/j.pan.2019.05.143.Peer-Reviewed Original ResearchManagement of patientsFamilial pancreatic cancerInternational CancerPancreatic cancerConsortium guidelinesCancerPatientsSa1350 – Updated International Cancer of the Pancreas Screening (CAPS) Consortium Guidelines on the Management of Patients with Increased Risk for Familial Pancreatic Cancer
Overbeek K, Canto M, Bartsch D, Brand R, Carrato A, Del Chiaro M, Farrell J, Fishman E, Fockens P, Gress T, van Hooft J, Kastrinos F, Rustgi A, Syngal S, Vasen H, Cahen D, Bruno M, Goggins M. Sa1350 – Updated International Cancer of the Pancreas Screening (CAPS) Consortium Guidelines on the Management of Patients with Increased Risk for Familial Pancreatic Cancer. Gastroenterology 2019, 156: s-323. DOI: 10.1016/s0016-5085(19)37637-1.Peer-Reviewed Original ResearchManagement of patientsFamilial pancreatic cancerInternational CancerPancreatic cancerConsortium guidelinesCancerPatients