2024
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals
Blackford A, Canto M, Dbouk M, Hruban R, Katona B, Chak A, Brand R, Syngal S, Farrell J, Kastrinos F, Stoffel E, Rustgi A, Klein A, Kamel I, Fishman E, He J, Burkhart R, Shin E, Lennon A, Goggins M. Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology 2024, 10: 1087-1096. PMID: 38959011, PMCID: PMC11223057, DOI: 10.1001/jamaoncol.2024.1930.Peer-Reviewed Original ResearchHigh-risk individualsSurveillance of high-risk individualsScreening programPancreatic ductal adenocarcinomaScreening high-risk individualsPancreatic cancer surveillanceUS academic medical centersPopulation-based screeningConditional logistic regressionUS national dataCox proportional hazards regressionAcademic medical centerLead-time biasProportional hazards regressionYear of diagnosisControl patientsRisk regression modelCancer surveillanceComparative cohort studyMain OutcomesComparison cohortOverall survivalCohort studyHazards regressionNational data
2023
Racial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance.
Klute K, Lucas A, Brand R, Everett J, Farrell J, Hawthorne K, Kaul V, Kupfer S, Paiella S, Simeone D, Sussman D, Zogopoulos G, Kastrinos F, Katona B, Consortium A. Racial, ethnic, and sex-based disparities among high-risk individuals undergoing pancreatic cancer surveillance. Journal Of Clinical Oncology 2023, 41: 687-687. DOI: 10.1200/jco.2023.41.4_suppl.687.Peer-Reviewed Original ResearchHigh-risk individualsSex-based disparitiesFamilial pancreatic cancerPDAC surveillancePancreatic cancer surveillancePeutz-Jeghers syndromeRates of consentSex-based differencesMedian ageAshkenazi Jewish ancestryMulticenter studyProspective studyCancer surveillancePancreatic cancerFamily historyLarge cohortMelanoma syndromeHereditary pancreatitisEarly detection researchStudy participantsEarly detectionStudy periodGermline DNACohortPDACPancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer.
Haimi I, Zogopoulos G, Dettwyler S, Everett J, Bi Y, Brand R, Chung D, Farrell J, Grossberg A, Kastrinos F, Katona B, Klute K, Kupfer S, Lucas A, Paiella S, Parmigiani G, Permuth J, Sears R, Sussman D, Simeone D, Consortium P. Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer. Journal Of Clinical Oncology 2023, 41: 689-689. DOI: 10.1200/jco.2023.41.4_suppl.689.Peer-Reviewed Original ResearchHigh-risk individualsPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCohort 1Worrisome featuresPancreatic cancerMain pancreatic duct diameterSolid massPancreatic duct diameterStandardized image acquisitionPGV groupGermline testingDuct stricturesIncurable stageMultiple cystsPancreatic abnormalitiesStandardized data collection systemNeuroendocrine tumorsDuctal adenocarcinomaCommon abnormalityFamily historyBenign lesionsLethal cancersPDAC risk
2022
SURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL
Blackford A, Canto M, Dbouk M, Kerdsirichairat T, Chak A, Brand R, Farrell J, Kastrinos F, Katona B, Rustgi A, Stoffel E, Syngal S, Klein A, Hruban R, Goggins M. SURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL. Gastrointestinal Endoscopy 2022, 95: ab544-ab545. DOI: 10.1016/j.gie.2022.04.1334.Peer-Reviewed Original Research
2021
Sa293 ASSESSMENT OF PROGRESSION OF CHRONIC PANCREATITIS-LIKE LESIONS IN HIGH RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE
Chhoda A, Merenda S, Farrell J. Sa293 ASSESSMENT OF PROGRESSION OF CHRONIC PANCREATITIS-LIKE LESIONS IN HIGH RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE. Gastroenterology 2021, 160: s-473-s-474. DOI: 10.1016/s0016-5085(21)01836-9.Peer-Reviewed Original Research
2019
67 Appraisal of Follow-up Protocols and Outcomes of High Risk Pancreatic Cancer Surveillance Programs: A Systematic Review and Meta-Analysis
Chhoda A, Mukherjee E, Wattamwar K, Kastrinos F, Farrell J. 67 Appraisal of Follow-up Protocols and Outcomes of High Risk Pancreatic Cancer Surveillance Programs: A Systematic Review and Meta-Analysis. The American Journal Of Gastroenterology 2019, 114: s40-s41. DOI: 10.14309/01.ajg.0000589800.17291.ef.Peer-Reviewed Original ResearchHigh-risk individualsCross-sectional imagingEndoscopic ultrasoundPancreatic cancerDiagnostic rateSectional imagingSystematic reviewPt-yrNew lesionsBaseline imagingAdvanced pathologyCumulative progression rateCancer Surveillance ProgramOptimal imaging modalityPre-existing abnormalitiesSignificant differencesOutcomes of interestRandom-effects modelFirst systematic reviewUncontrolled studiesProspective studySubgroup analysisSurveillance protocolHistologic diagnosisProgression rate