2024
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals
Blackford A, Canto M, Dbouk M, Hruban R, Katona B, Chak A, Brand R, Syngal S, Farrell J, Kastrinos F, Stoffel E, Rustgi A, Klein A, Kamel I, Fishman E, He J, Burkhart R, Shin E, Lennon A, Goggins M. Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology 2024, 10: 1087-1096. PMID: 38959011, PMCID: PMC11223057, DOI: 10.1001/jamaoncol.2024.1930.Peer-Reviewed Original ResearchHigh-risk individualsSurveillance of high-risk individualsScreening programPancreatic ductal adenocarcinomaScreening high-risk individualsPancreatic cancer surveillanceUS academic medical centersPopulation-based screeningConditional logistic regressionUS national dataCox proportional hazards regressionAcademic medical centerLead-time biasProportional hazards regressionYear of diagnosisControl patientsRisk regression modelCancer surveillanceComparative cohort studyMain OutcomesComparison cohortOverall survivalCohort studyHazards regressionNational data
2023
Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer.
Haimi I, Zogopoulos G, Dettwyler S, Everett J, Bi Y, Brand R, Chung D, Farrell J, Grossberg A, Kastrinos F, Katona B, Klute K, Kupfer S, Lucas A, Paiella S, Parmigiani G, Permuth J, Sears R, Sussman D, Simeone D, Consortium P. Pancreatic imaging findings from the PRECEDE study: A large high-risk heritable cohort for pancreatic cancer. Journal Of Clinical Oncology 2023, 41: 689-689. DOI: 10.1200/jco.2023.41.4_suppl.689.Peer-Reviewed Original ResearchHigh-risk individualsPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCohort 1Worrisome featuresPancreatic cancerMain pancreatic duct diameterSolid massPancreatic duct diameterStandardized image acquisitionPGV groupGermline testingDuct stricturesIncurable stageMultiple cystsPancreatic abnormalitiesStandardized data collection systemNeuroendocrine tumorsDuctal adenocarcinomaCommon abnormalityFamily historyBenign lesionsLethal cancersPDAC risk
2022
SURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL
Blackford A, Canto M, Dbouk M, Kerdsirichairat T, Chak A, Brand R, Farrell J, Kastrinos F, Katona B, Rustgi A, Stoffel E, Syngal S, Klein A, Hruban R, Goggins M. SURVEILLANCE OF HIGH-RISK INDIVIDUALS LEADS TO LOWER STAGE PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) AT DIAGNOSIS AND IMPROVED OVERALL AND DISEASE-SPECIFIC SURVIVAL. Gastrointestinal Endoscopy 2022, 95: ab544-ab545. DOI: 10.1016/j.gie.2022.04.1334.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaDisease-specific survivalHigh-risk individualsDuctal adenocarcinomaAdenocarcinomaThe PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer.
Zogopoulos G, Bi Y, Brand R, Chung D, Earl J, Farrell J, Graff J, Kastrinos F, Katona B, Klute K, Koptiuch C, Kupfer S, Kwon R, Lindberg J, Lowy A, Lucas A, Paiella S, Permuth J, Sears R, Simeone D, Consortium T. The PRECEDE consortium: A longitudinal international cohort study of individuals with genetic risk or familial pancreatic cancer. Journal Of Clinical Oncology 2022, 40: e16239-e16239. DOI: 10.1200/jco.2022.40.16_suppl.e16239.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaPathogenic germline variantsFamilial pancreatic cancerCancer predisposition genesCohort studyPancreatic cancerClinical dataAnnual surveillanceEffective early detection strategiesHigh-quality clinical dataHigh-risk premalignant lesionsModifiers of riskInternational cohort studyProspective cohort studyEarly-stage diseaseOverall survival rateEarly detection strategiesEarly-stage cancerBlood sample collectionRelevant clinical populationContribution of heritabilityPenetrance of diseaseQuality clinical dataParticipants ages 18Germline testing
2020
Sa1154 ORGANOID-BASED PRECLINICAL MODELS RECAPITULATE RENALASE SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA
Nair G, Yoo J, Gao Y, Desir G, Gorelick F, Farrell J, Foster G, Joshi N. Sa1154 ORGANOID-BASED PRECLINICAL MODELS RECAPITULATE RENALASE SIGNALING IN PANCREATIC DUCTAL ADENOCARCINOMA. Gastroenterology 2020, 158: s-293. DOI: 10.1016/s0016-5085(20)31426-8.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaDuctal adenocarcinoma