2018
Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts
Laird J, Lok B, Ma J, Bell A, de Stanchina E, Poirier J, Rudin C. Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts. Clinical Cancer Research 2018, 24: 5143-5152. PMID: 29945991, PMCID: PMC6742772, DOI: 10.1158/1078-0432.ccr-18-0401.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorCell SurvivalDisease Models, AnimalDNA Breaks, Double-StrandedDose-Response Relationship, DrugHumansPhthalazinesPoly(ADP-ribose) Polymerase InhibitorsRadiation ToleranceRadiation-Sensitizing AgentsRadiation, IonizingSmall Cell Lung CarcinomaXenograft Model Antitumor AssaysConceptsSmall cell lung cancerSCLC cell linesClonogenic survival assaysCell linesPatient-derived xenograft modelsPARP inhibitionShort-term viability assaysDoses of veliparibCell lung cancerClin Cancer ResEfficacy of radiotherapyTumor growth inhibitionViability assaysAggressive malignancyLung cancerPDX modelsNovel therapiesSCLC cellsXenograft modelSingle agentPARP inhibitorsCancer ResTalazoparibSurvival assaysContribution of PARP
2017
Unravelling the biology of SCLC: implications for therapy
Sabari J, Lok B, Laird J, Poirier J, Rudin C. Unravelling the biology of SCLC: implications for therapy. Nature Reviews Clinical Oncology 2017, 14: 549-561. PMID: 28534531, PMCID: PMC5843484, DOI: 10.1038/nrclinonc.2017.71.Peer-Reviewed Original ResearchConceptsBiology of SCLCHigh-grade neuroendocrine tumorsPARP inhibitor veliparibImmune checkpoint blockadeEncouraging clinical activityPoor overall survivalHigh mutational burdenImmune checkpoint proteinsZeste homologue 2Antibody-drug conjugatesOverall survivalRovalpituzumab tesirineLung cancerNeuroendocrine tumorsClinical trialsClinical activityMutational burdenNew therapiesTherapeutic targetingProtein 3SCLCHomologue 2PatientsPromising activityTherapy