2018
Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies
Ma J, Laird J, Chau K, Chelius M, Lok B, Yahalom J. Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies. Cancer Medicine 2018, 8: 58-66. PMID: 30597769, PMCID: PMC6346231, DOI: 10.1002/cam4.1844.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overFemaleHistiocytosis, Langerhans-CellHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedNeoplasmsPrevalenceConceptsLangerhans cell histiocytosisAdult LCH patientsAdditional malignanciesLCH patientsLCH diagnosisCell histiocytosisSolid malignanciesHigh prevalenceSingle institution experienceCause of malignancyYears of ageOncologic historyConsecutive patientsMedian ageHistiocyte proliferationHematologic malignanciesRare disorderLCH treatmentRare diseasePatientsMalignancySolid tumorsTumorigenic agentsHistiocytosisCohort
2017
Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy
Laird J, Lok B, Siu C, Cahlon O, Khan A, McCormick B, Powell S, Cody H, Wen H, Ho A, Braunstein L. Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy. Annals Of Surgical Oncology 2017, 25: 154-163. PMID: 29094250, PMCID: PMC5827945, DOI: 10.1245/s10434-017-6209-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMastectomy, SegmentalMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNeoplasms, Second PrimaryProportional Hazards ModelsRadiotherapy, AdjuvantSurvival RateConceptsDisease-free survivalBreast-conserving therapyBreast tumor recurrenceTrue recurrenceNew primarySitu componentOverall survivalTumor sizeTumor recurrenceFive-year disease-free survivalTR groupCox proportional hazards regression modelLower disease-free survivalWorse disease-free survivalProportional hazards regression modelsSimultaneous distant metastasesKaplan-Meier methodHazards regression modelsLog-rank testAxillary surgeryDFS eventsNode involvementLymphovascular invasionMargin statusUnresectable recurrence