2018
Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies
Ma J, Laird J, Chau K, Chelius M, Lok B, Yahalom J. Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies. Cancer Medicine 2018, 8: 58-66. PMID: 30597769, PMCID: PMC6346231, DOI: 10.1002/cam4.1844.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overFemaleHistiocytosis, Langerhans-CellHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedNeoplasmsPrevalenceConceptsLangerhans cell histiocytosisAdult LCH patientsAdditional malignanciesLCH patientsLCH diagnosisCell histiocytosisSolid malignanciesHigh prevalenceSingle institution experienceCause of malignancyYears of ageOncologic historyConsecutive patientsMedian ageHistiocyte proliferationHematologic malignanciesRare disorderLCH treatmentRare diseasePatientsMalignancySolid tumorsTumorigenic agentsHistiocytosisCohort
2017
Outcome After Radiation Therapy for Langerhans Cell Histiocytosis Is Dependent on Site of Involvement
Laird J, Ma J, Chau K, Chelius M, Shi W, Zhang Z, Lok B, Yahalom J. Outcome After Radiation Therapy for Langerhans Cell Histiocytosis Is Dependent on Site of Involvement. International Journal Of Radiation Oncology • Biology • Physics 2017, 100: 670-678. PMID: 29413280, PMCID: PMC5806138, DOI: 10.1016/j.ijrobp.2017.10.053.Peer-Reviewed Original ResearchConceptsRadiation therapyLocal failureLocal recurrenceMultisystem involvementBone lesionsHigh riskSite of involvementAdditional treatment modalitiesLymph node lesionsLangerhans cell histiocytosisSite of lesionRadiologic responseMedian dosePatient demographicsIrradiated lesionsLymph nodesMedian ageNode lesionsLCH patientsMultisystem diseaseCell histiocytosisTreatment modalitiesMultiple time pointsBrain lesionsSkin lesions