2023
Characterization and diagnosis spectrum of patients with cerebrospinal fluid pleocytosis
Dyckhoff-Shen S, Bewersdorf J, Teske N, Völk S, Pfister H, Koedel U, Klein M. Characterization and diagnosis spectrum of patients with cerebrospinal fluid pleocytosis. Infection 2023, 52: 219-229. PMID: 37656347, PMCID: PMC10811117, DOI: 10.1007/s15010-023-02087-8.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid pleocytosisCerebrospinal fluid cell countBacterial meningitisCerebrospinal fluidCNS infectionCell countElevated white blood cell countResultsThe most common etiologyMethodsA retrospective cohort studyNeoplastic diseaseAutoimmune CNS diseaseWhite blood cell countRetrospective cohort studySpectrum of patientsCharacteristics of patientsBlood cell countCerebrospinal fluid proteinAbnormal mental statusLaboratory featuresCSF pleocytosisCSF leukocytesLaboratory parametersClinical presentationNuchal rigidityCommon etiologies
2018
Novel and preclinical treatment strategies in pneumococcal meningitis
Bewersdorf J, Grandgirard D, Koedel U, Leib S. Novel and preclinical treatment strategies in pneumococcal meningitis. Current Opinion In Infectious Diseases 2018, 31: 85-92. PMID: 29095719, DOI: 10.1097/qco.0000000000000416.Peer-Reviewed Original ResearchConceptsAdjuvant therapyPneumococcal meningitisNew adjuvant therapiesSystematic clinical testingProtein-based pneumococcal vaccinesPreclinical treatment strategiesPneumococcal conjugate vaccineAnti-inflammatory therapyImprove disease outcomesToxic bacterial productsMatrix metalloproteinase inhibitorsNonbacteriolytic antibioticsAdjuvant dexamethasoneLife-threatening diseaseMeningeal inflammationBacterial meningitisSerotype replacementTreatment optionsConjugate vaccinePneumococcal vaccineMorbidity rateComplement inhibitorsTreatment strategiesSuppress inflammationMeningitis