2024
Pacritinib Response Is Associated With Overall Survival in Myelofibrosis: PERSIST‐2 Landmark Analysis of Survival
Ajufo H, Bewersdorf J, Harrison C, Palandri F, Mascarenhas J, Palmer J, Gerds A, Kiladjian J, Buckley S, Derkach A, Roman‐Torres K, Rampal R. Pacritinib Response Is Associated With Overall Survival in Myelofibrosis: PERSIST‐2 Landmark Analysis of Survival. European Journal Of Haematology 2024 PMID: 39400386, DOI: 10.1111/ejh.14321.Peer-Reviewed Original ResearchSpleen volume reductionOverall survivalOS benefitNon-respondersAssociated with improved OSPatients treated with ruxolitinibAssociated with overall survivalAssociated with significant OS benefitImproved overall survivalSignificant OS benefitPERSIST-2Analysis of survivalUnique survival advantagesInhibitor of Janus kinaseJanus kinaseOS curvesRetrospective analysisSurvival advantageMyelofibrosisPacritinibPatientsRuxolitinibPlateletThrombocytopeniaVolume reduction
2023
A phase I study of ruxolitinib in combination with abemaciclib for patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis.
Bewersdorf J, Verstovsek S, Derkach A, Masarova L, Pemmaraju N, Stein E, Mauro M, Rampal R, Bose P. A phase I study of ruxolitinib in combination with abemaciclib for patients with primary or post-polycythemia vera/essential thrombocythemia myelofibrosis. Journal Of Clinical Oncology 2023, 41: tps7086-tps7086. DOI: 10.1200/jco.2023.41.16_suppl.tps7086.Peer-Reviewed Original ResearchCDK4/6 inhibitorsSymptom scoresPhase I dose-escalation trialMedian overall survivalMD Anderson Cancer CenterDose-escalation designDuration of responseMaximum tolerated doseSafety of ruxolitinibSpleen volume reductionBiomarkers of responseHigh-risk diseasePhase I studyTreated with increasing dosesDose of ruxolitinibOral Janus kinaseLeft costal marginJanus kinase inhibitorsCDK4/6 inhibitor abemaciclibIncreased expression of CDC25AMechanism-based therapiesMeasures of efficacyFDA-approved CDK4/6 inhibitorsAge-matched controlsJanus kinase