2022
Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia
Stahl M, Derkach A, Farnoud N, Bewersdorf J, Robinson T, Famulare C, Cho C, Devlin S, Menghrajani K, Patel M, Cai S, Miles L, Bowman R, Geyer M, Dunbar A, Epstein‐Peterson Z, McGovern E, Schulman J, Glass J, Taylor J, Viny A, Stein E, Getta B, Arcila M, Gao Q, Barker J, Shaffer B, Papadopoulos E, Gyurkocza B, Perales M, Abdel‐Wahab O, Levine R, Giralt S, Zhang Y, Xiao W, Pai N, Papaemmanuil E, Tallman M, Roshal M, Goldberg A. Molecular predictors of immunophenotypic measurable residual disease clearance in acute myeloid leukemia. American Journal Of Hematology 2022, 98: 79-89. PMID: 36251406, PMCID: PMC10080561, DOI: 10.1002/ajh.26757.Peer-Reviewed Original ResearchConceptsMeasurable residual diseaseAcute myeloid leukemiaAllo-SCTInduction chemotherapyPersistent diseaseMyeloid leukemiaAllogeneic stem cell transplantationStem cell transplantationMonosomy 5Residual diseaseDisease clearanceKaryotypic abnormalitiesPrognostic factorsCell transplantationMolecular predictorsMRD clearanceRemissionClinical trialsNext-generation sequencingChemotherapyPatientsMutation patternsTherapyLeukemiaMRD
2015
The SPEED (sepsis patient evaluation in the emergency department) score
Bewersdorf J, Hautmann O, Kofink D, Khalil A, Abidin I, Loch A. The SPEED (sepsis patient evaluation in the emergency department) score. European Journal Of Emergency Medicine 2015, 24: 170-175. PMID: 26524675, PMCID: PMC5417572, DOI: 10.1097/mej.0000000000000344.Peer-Reviewed Original ResearchConceptsSeptic patientsEmergency Department Sepsis scoreSevere inflammatory response syndromeScoring systemImmune-suppressed stateMortality rateInflammatory response syndromeArea under the curveStratify mortality riskReceiver operating characteristic curveHospital mortality rateSystolic blood pressureEmergency departmentMortality riskAdmission diagnosisPrognostic factorsResponse syndromePrimary outcomeSepsis scoreLaboratory valuesSource of infectionPatient characteristicsStudy populationSpeed scoresBlood pressure