2024
IL-10 constrains sphingolipid metabolism to limit inflammation
York A, Skadow M, Oh J, Qu R, Zhou Q, Hsieh W, Mowel W, Brewer J, Kaffe E, Williams K, Kluger Y, Smale S, Crawford J, Bensinger S, Flavell R. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 2024, 627: 628-635. PMID: 38383790, PMCID: PMC10954550, DOI: 10.1038/s41586-024-07098-5.Peer-Reviewed Original ResearchActivity of RelCeramide productionVery long chainFatty acid synthesis pathwayCeramide synthase 2Fatty acid homeostasisMetabolic fluxAvailable to cellsRegulatory nodesTranscription factorsCeramide accumulationSynthesis pathwayVLC ceramidesIL-10 deficiencyGene expressionSphingolipid metabolismAcid homeostasisAberrant activationIL-10Cell types1Innate immune cellsInflammatory gene expressionCeramideSignaling resultsGenetic deletion
2019
Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior
Lozano GL, Bravo JI, Diago M, Park HB, Hurley A, Peterson SB, Stabb EV, Crawford JM, Broderick NA, Handelsman J. Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior. MBio 2019, 10: 10.1128/mbio.02846-18. PMID: 30837345, PMCID: PMC6401489, DOI: 10.1128/mbio.02846-18.Peer-Reviewed Original ResearchConceptsGenetic dissectionModel communitiesCommunity-level interactionsMicrobial community behaviorRhizosphere microbiomeModel microbiomeMicrobiome assemblyEmergent propertiesHistory of biologyMicrobial communitiesMammalian gutRobust biofilmsDominant phylaGene expressionBiochemical toolsRhizosphereCommunity interactionsNovel familyHitchhikersMicrobiomeFlavobacteriumModel systemCommunity behaviorPseudomonasAgricultural productivity