2024
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca
Hamchand R, Wang K, Song D, Palm N, Crawford J. Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca. Nature Communications 2024, 15: 8902. PMID: 39406708, PMCID: PMC11480411, DOI: 10.1038/s41467-024-53185-6.Peer-Reviewed Original ResearchConceptsK. oxytocaGeneral carbohydrate metabolismVirulence factor productionPLP-dependent enzymesAssociated with gutEnterobactin biosynthesisAutoinducer signalBacterial virulenceKlebsiella oxytocaSpecific carbohydratesHost immune responseCarbohydrate metabolismAutoinducerMolecular signalsVirulenceHistamine receptor H4BiosynthesisHost signalAcquisition responsesProtease inhibitorsPathwayHostLung pathologyLung isolationImmune response
2020
Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli
Kim CS, Li JH, Barco B, Park HB, Gatsios A, Damania A, Wang R, Wyche TP, Piizzi G, Clay NK, Crawford JM. Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli. Cell Chemical Biology 2020, 27: 698-707.e7. PMID: 32243812, PMCID: PMC7306003, DOI: 10.1016/j.chembiol.2020.03.003.Peer-Reviewed Original ResearchConceptsPlant-pathogen defense responsesPlant innate immune responsesPathogen defense responsesSmall molecule signalsEscherichia coliPersister cell formationStress-induced metabolitesPrimary human tissuesDefense responsesRedox stressorsInnate immune responseDistinct immunological responsesMolecule signalsMolecular studiesCell formationColiBacterial metabolitesDefensive responsesSmall moleculesPlantsHuman tissuesImmune responseImmunological responseInfection modelMetabolites
2018
β‑Lactam Biotransformations Activate Innate Immunity
Oh J, Patel J, Park HB, Crawford JM. β‑Lactam Biotransformations Activate Innate Immunity. The Journal Of Organic Chemistry 2018, 83: 7173-7179. PMID: 29616809, DOI: 10.1021/acs.joc.8b00241.Peer-Reviewed Original ResearchConceptsHuman microbiota compositionImmune responseImmune functionMicrobiota compositionInnate immunityBroad immunomodulatory mechanismPatient's immune responseClinical trial studyCommon resistance determinantsMicrobiome-dependent mannerImmunomodulatory mechanismsNF-κBTrial studyBacterial infectionsImmunomodulatory interactionsMinimal long-term impactAntibioticsΒ-lactamaseAmoxicillinHuman leukemic monocytesLeukemic monocytesResistance determinantsBiotransformation productsImmunityMolecular mechanisms