2024
Bacterial small molecule metabolites implicated in gastrointestinal cancer development
Turocy T, Crawford J. Bacterial small molecule metabolites implicated in gastrointestinal cancer development. Nature Reviews Microbiology 2024, 1-16. PMID: 39375475, DOI: 10.1038/s41579-024-01103-4.Peer-Reviewed Original ResearchSmall molecule metabolitesGastrointestinal cancer developmentAssociated with cancer progressionHost–microorganism interactionsGastrointestinal cancerCancer riskCancer developmentCancer progressionCancerTherapeutic interventionsMicrobiome membersHuman microbiomeBacterial speciesGlobal causeMolecular mechanismsMetabolitesRisk
2017
Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior
Fischer C, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior. ELife 2017, 6: e18855. PMID: 28068220, PMCID: PMC5222558, DOI: 10.7554/elife.18855.Peer-Reviewed Original ResearchConceptsMicrobial communitiesContext-dependent fitness benefitsMulti-species microbial communitiesMicrobial community influencesMicrobe-microbe interactionsEgg-laying preferenceInter-species interactionsEgg-laying behaviorHost-microbiome interactionsDistinct volatile profileMicrobiome membersFitness benefitsMetabolite exchangePopulation declineDrosophila behaviorMolecular mechanismsOlfactory receptorsMetabolic derivativesEthanol catabolismAnimal behaviorCurrent understandingMicrobiomeOr42bIndividual membersDrosophila