2020
Dimeric Stilbene Antibiotics Target the Bacterial Cell Wall in Drug-Resistant Gram-Positive Pathogens
Goddard TN, Patel J, Park HB, Crawford JM. Dimeric Stilbene Antibiotics Target the Bacterial Cell Wall in Drug-Resistant Gram-Positive Pathogens. Biochemistry 2020, 59: 1966-1971. PMID: 32410442, PMCID: PMC10578317, DOI: 10.1021/acs.biochem.0c00213.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsCell WallDrug Resistance, BacterialEnterococcus faeciumHumansMethicillinMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureStilbenesVancomycinConceptsChemical complementation studiesBacterial cell wallMass spectrometry analysisLipid IILead compoundsMultidrug-resistant Gram-positive pathogensStilbene dimersCell wall precursorsSpectrometry analysisDrug-Resistant GramNew antimicrobial agentsGram-positive pathogensDimersNonlethal exposureAntibiotic targetsPositive pathogensDietary plantsAction studiesAntibiotic resistanceMode of actionAntimicrobial agentsLead dimerWall precursorsMonomersStrong activity
2017
A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase
Trautman EP, Crawford JM. A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase. Biochemistry 2017, 56: 4923-4924. PMID: 28885002, DOI: 10.1021/acs.biochem.7b00680.Peer-Reviewed Original ResearchAnimalsAnti-Bacterial AgentsDNA-Directed RNA PolymerasesEnzyme InhibitorsHumansMethicillin-Resistant Staphylococcus aureusMiceNucleosidesStreptococcus pneumoniae