Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection
Yang J, Schleicher TR, Dong Y, Park HB, Lan J, Cresswell P, Crawford J, Dimopoulos G, Fikrig E. Disruption of mosGILT in Anopheles gambiae impairs ovarian development and Plasmodium infection. Journal Of Experimental Medicine 2019, 217: e20190682. PMID: 31658986, PMCID: PMC7037243, DOI: 10.1084/jem.20190682.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAnophelesClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Associated Protein 9CulicidaeFemaleMalariaMaleMiceMutationOxidoreductases Acting on Sulfur Group DonorsPlasmodium bergheiPlasmodium falciparumRNA-Binding ProteinsVitellogeninsConceptsMutant mosquitoesOvarian developmentThioester-containing protein 1Rodent Plasmodium speciesMajor yolk proteinInducible lysosomal thiol reductaseAbility of sporozoitesExpression of vitellogeninLysosomal thiol reductaseAnopheles gambiae mosquitoesPlasmodium infectionMosquito immunityProtein 9Yolk proteinsThiol reductaseVertebrate hostsTraverse cellsMosquito factorsGambiae mosquitoesProtein 1Plasmodium speciesAnophelesMosquitoesMosaic mutationsParasite killing