2019
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
Kneissig M, Keuper K, de Pagter MS, van Roosmalen MJ, Martin J, Otto H, Passerini V, Sparr A, Renkens I, Kropveld F, Vasudevan A, Sheltzer JM, Kloosterman WP, Storchova Z. Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. ELife 2019, 8: e50292. PMID: 31778112, PMCID: PMC6910827, DOI: 10.7554/elife.50292.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell NucleusChromothripsisDNA DamageDNA ReplicationGenomic InstabilityHumansLamin Type BMiceMicronuclei, Chromosome-DefectiveConceptsMassive chromosomal rearrangementsChromosomal rearrangementsHuman cellsLamin B1Replication-dependent mechanismModel systemMicronucleus sizeProper assemblyAberrant replicationChromosome shatteringChromosome transferMembrane curvatureNuclear envelopeExtra chromosomeAberrant structuresDNA damageChromosomesGrowth advantageFunctional consequencesCancer cellsAbnormal numberTrisomic cellsCellsChromosomal aberrationsRearrangement
2017
Single-chromosome Gains Commonly Function as Tumor Suppressors
Sheltzer J, Ko J, Replogle J, Burgos N, Chung E, Meehl C, Sayles N, Passerini V, Storchova Z, Amon A. Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell 2017, 31: 240-255. PMID: 28089890, PMCID: PMC5713901, DOI: 10.1016/j.ccell.2016.12.004.Peer-Reviewed Original ResearchConceptsSingle chromosome gainsSingle extra chromosomeEffects of aneuploidyHallmarks of cancerEvolutionary flexibilityFitness defectsEuploid cellsTumor suppressorExtra chromosomeEuploid counterpartsOncogenic pathwaysProlonged growthChromosomal alterationsCancer developmentCell linesTrisomic cellsImproved fitnessAneuploidyTrisomic cell lineCellsChromosomesSuppressorAdditional chromosomal alterationsGrowthTumorigenesis
2011
Aneuploidy Drives Genomic Instability in Yeast
Sheltzer J, Blank H, Pfau S, Tange Y, George B, Humpton T, Brito I, Hiraoka Y, Niwa O, Amon A. Aneuploidy Drives Genomic Instability in Yeast. Science 2011, 333: 1026-1030. PMID: 21852501, PMCID: PMC3278960, DOI: 10.1126/science.1206412.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyChromosome SegregationChromosomes, FungalDNA DamageDNA RepairDNA ReplicationDNA, FungalGenome, FungalGenomic InstabilityMutagenesisMutationNeoplasmsPhenotypeRad52 DNA Repair and Recombination ProteinRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsGenomic instabilityMitotic recombinationDefective DNA damage repairEffects of aneuploidyDNA damage repairCellular fitnessFission yeastGenomic stabilitySingle chromosomeEnhanced proliferative capacityChromosome lossDamage repairExtra copiesYeastGenetic alterationsProliferative capacityAneuploidyMost strainsMalignant growthRecombinationChromosomesTumorigenesisFitnessCopiesGrowth