Single-chromosome Gains Commonly Function as Tumor Suppressors
Sheltzer J, Ko J, Replogle J, Burgos N, Chung E, Meehl C, Sayles N, Passerini V, Storchova Z, Amon A. Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell 2017, 31: 240-255. PMID: 28089890, PMCID: PMC5713901, DOI: 10.1016/j.ccell.2016.12.004.Peer-Reviewed Original ResearchConceptsSingle chromosome gainsSingle extra chromosomeEffects of aneuploidyHallmarks of cancerEvolutionary flexibilityFitness defectsEuploid cellsTumor suppressorExtra chromosomeEuploid counterpartsOncogenic pathwaysProlonged growthChromosomal alterationsCancer developmentCell linesTrisomic cellsImproved fitnessAneuploidyTrisomic cell lineCellsChromosomesSuppressorAdditional chromosomal alterationsGrowthTumorigenesis