2000
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.
Chakraborty A, Sodi S, Rachkovsky M, Kolesnikova N, Platt J, Bolognia J, Pawelek J. A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer Research 2000, 60: 2512-9. PMID: 10811133.Peer-Reviewed Original ResearchMeSH KeywordsAminopterinAnimalsAnti-Bacterial AgentsAntigens, CDAntineoplastic Combined Chemotherapy ProtocolsCell MovementChemotaxisFlow CytometryGentamicinsHypoxanthineImmunoblottingLung NeoplasmsLysosome-Associated Membrane GlycoproteinsMelanomaMembrane GlycoproteinsMiceMice, Inbred BALB CMicroscopy, ElectronMonophenol MonooxygenaseNeoplasm TransplantationPolymorphism, Restriction Fragment LengthSequence Analysis, DNAThymidineTime FactorsTumor Cells, Cultured
1998
Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism
SODI S, CHAKRABORTY A, PLATT J, KOLESNIKOVA N, ROSEMBLAT S, KEH‐YEN A, BOLOGNIA J, RACHKOVSKY M, ORLOW S, PAWELEK J. Melanoma × Macrophage Fusion Hybrids Acquire Increased Melanogenesis and Metastatic Potential: Altered N‐Glycosylation as an Underlying Mechanism. Pigment Cell & Melanoma Research 1998, 11: 299-309. PMID: 9877101, DOI: 10.1111/j.1600-0749.1998.tb00739.x.Peer-Reviewed Original ResearchConceptsN-glycosylationLAMP-1Parental cellsN-glycosylation inhibitorMelanoma cellsCloudman S91 cellsMetastatic potentialImportant regulatory pathwayAltered N-glycosylationMajority of hybridsParental melanoma cellsCloudman S91 melanoma cellsRegulatory pathwaysMelanosomal proteinsCloudman melanoma cellsMelanotic phenotypeSame proteinS91 melanoma cellsIncreased glycosylationPigmentary systemCell lysatesS91 cellsUnderlying mechanismCloudman cellsGel electrophoresisMelanoma × macrophage hybrids with enhanced metastatic potential
Rachkovsky M, Sodi S, Chakraborty A, Avissar Y, Bolognia J, Madison McNiff J, Platt J, Bermudes D, Pawelek J. Melanoma × macrophage hybrids with enhanced metastatic potential. Clinical & Experimental Metastasis 1998, 16: 299-312. PMID: 9626809, DOI: 10.1023/a:1006557228604.Peer-Reviewed Original ResearchConceptsHigh metastatic potentialMetastatic potentialMelanoma cellsTumor-infiltrating leukocytesParental melanoma cellsLow metastatic potentialB16F10 melanoma cellsFibroblast-conditioned mediumCloudman S91 mouse melanoma cellsMetastatic melanoma cellsS91 mouse melanoma cellsVascular invasionMetastatic melanomaPrimary tumorNormal miceMelanoma metastasesEnhanced metastasisMetastasisDistant organsUseful new modelMouse melanoma cellsHigher chemotaxisMetastatic linesHuman macrophagesTumor cells
1994
Effects of Ultraviolet Irradiation on the Cell Cycle
BOLOGNIA J, SODI S, CHAKRABORTY A, FARGNOLI M, PAWELEK J. Effects of Ultraviolet Irradiation on the Cell Cycle. Pigment Cell & Melanoma Research 1994, 7: 320-325. PMID: 7886005, DOI: 10.1111/j.1600-0749.1994.tb00634.x.Peer-Reviewed Original ResearchConceptsMSH receptor activityG2/M phaseReceptor activityMelanoma cellsCloudman melanoma cellsM phaseCell cycleHr post irradiationBreast carcinoma cellsG2/M accumulationReceptor binding activityEffects of UVBAccumulation of cellsGeneralized cellular responseInjury responseUVB irradiationFlow cytometryCloudman cellsCarcinoma cellsG2/MNumber of cellsM accumulationCell linesTreatmentUVB radiation
1989
UVB-Induced melanogenesis may be mediated through the MSH-receptor system
Bolognia J, Murray M, Pawelek J. UVB-Induced melanogenesis may be mediated through the MSH-receptor system. Journal Of Investigative Dermatology 1989, 92: 651-656. DOI: 10.1016/0022-202x(89)90177-2.Peer-Reviewed Original ResearchMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSHUVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System
Bolognia J, Murray M, Pawelek J. UVB-Induced Melanogenesis May Be Mediated Through the MSH-Receptor System. Journal Of Investigative Dermatology 1989, 92: 651-656. PMID: 2497190, DOI: 10.1111/1523-1747.ep12696836.Peer-Reviewed Original ResearchConceptsMSH receptor activityUltraviolet B radiationReceptor activityMSH binding capacityMSH receptor systemMelanin-producing melanocytesUVB-induced melanogenesisHigh-affinity receptorGuinea pig skinEffects of UVBCloudman S91 mouse melanoma cellsS91 mouse melanoma cellsFamily of peptidesCutaneous melanocytesGuinea pigsMouse melanoma cellsAffinity receptorMelanoma cellsCellular responsivenessB radiationPig skinUVB lightCutaneous melanogenesisMelanocytesMSH