2017
Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies
Hendrickson J. Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies. ISBT Science Series 2017, 13: 105-111. DOI: 10.1111/voxs.12360.Peer-Reviewed Original ResearchAnimal modelsChronic inflammatory disease statesRBC unitsAntigen-specific toleranceT-cell markersInduction of immunityInflammatory disease statesHumoral immune responseHumoral immune responsivenessAlloantibody developmentRBC alloimmunisationDonor antigensDendritic cellsRBC alloantibodiesRBC transfusionTransfusion recipientsImmune responsivenessRBC exposureRisk factorsMurine studiesForeign antigensImmune responseCD 4Danger signalsImmune system
2013
Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models
Hendrickson J. Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models. Blood 2013, 122: sci-49. DOI: 10.1182/blood.v122.21.sci-49.sci-49.Peer-Reviewed Original ResearchRed blood cellsMurine red blood cellsPreventive therapyRBC alloantibodiesTransfusion settingsRBC precursorsHemolytic diseaseAnimal modelsAntigen-negative red blood cellsNewborn pupsRed blood cell alloimmunizationPositive indirect antiglobulin testBone marrow erythroid precursorsMature red blood cellsFetal liverNegative red blood cellsPotential preventive therapyRBC-specific expressionRh immune globulinFlow cytometric crossmatchPregnancy/deliveryFetus/neonateForeign red blood cellsWeeks of deliveryIndirect antiglobulin test
2011
A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization
Smith N, Henry K, Zimring J, Hendrickson J. A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization. Blood 2011, 118: 715. DOI: 10.1182/blood.v118.21.715.715.Peer-Reviewed Original ResearchNon-immunized mothersRBC alloimmunizationNovel murine modelGlycoprotein antibodiesC57BL/6 recipientsImmunized mothersNegative fetusMurine modelAnimal modelsC57BL/6 femalesMechanisms of immunizationRBC-specific expressionSubset of pregnanciesFlow cytometric crossmatchSubtype-specific antibodiesDays of lifeFirst animal modelAnti-Kell antibodiesPrior pregnancySubsequent transfusionsCytometric crossmatchRBC transfusionAntibody titersRepeat pregnancyRBC antibodies
2010
Use of mouse models to study the mechanisms and consequences of RBC clearance
Hod E, Arinsburg S, Francis R, Hendrickson J, Zimring J, Spitalnik S. Use of mouse models to study the mechanisms and consequences of RBC clearance. Vox Sanguinis 2010, 99: 99-111. PMID: 20345515, PMCID: PMC3580149, DOI: 10.1111/j.1423-0410.2010.01327.x.Peer-Reviewed Original ResearchConceptsMouse modelRBC clearanceImmune globulin therapyAutoimmune haemolytic anaemiaHaemolytic transfusion reactionsGlobulin therapyRBC transfusionTransfusion reactionsHaemolytic anaemiaAnimal modelsTractable animal modelTransfusion medicineCell clearanceClearancePathophysiologyHuman disordersUnanswered questionsTransfusionComplicationsAnemiaImmunomodulationTherapyMiceAntibodies