2021
Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease
Madany E, Lee J, Halprin C, Seo J, Baca N, Majlessipour F, Hendrickson JE, Pepkowitz SH, Hayes C, Klapper E, Gibb DR. Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease. EJHaem 2021, 2: 700-710. PMID: 35128535, PMCID: PMC8813163, DOI: 10.1002/jha2.270.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsSickle cell diseaseCell diseaseRace-matched healthy controlsType 1 interferon responseFrequency of alloimmunizationNon-alloimmunized patientsBlood mononuclear cellsType 1 interferonExpression of ISGsGene scoreNonalloimmunized patientsRBC alloimmunizationPlasma cytokinesSCD patientsMononuclear cellsHealthy controlsHigh prevalenceBlood leukocytesAlloimmunizationViral immunityPatientsIFNISG expressionInterferon response
2020
Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization
Madany E, Lee J, Hendrickson J, Gibb D. Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization. Blood 2020, 136: 26-27. DOI: 10.1182/blood-2020-142935.Peer-Reviewed Original ResearchFrequency of alloimmunizationInterferon Stimulated GenesHigher IFN scoresInterferon gene signatureSS patientsSickle cell patientsIFN scoreSickle cell diseaseSS diseaseHealthy controlsGene signatureRBC alloimmunizationCell patientsCell diseaseType I interferon gene signaturePeripheral blood mononuclear cellsSickle cell disease patientsInflammatory autoimmune diseaseWhole bloodChronic inflammatory stateType 1 IFNBlood mononuclear cellsIFN gene signatureType 1 interferonMyxovirus resistance protein 1