2011
A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization
Smith N, Henry K, Zimring J, Hendrickson J. A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization. Blood 2011, 118: 715. DOI: 10.1182/blood.v118.21.715.715.Peer-Reviewed Original ResearchNon-immunized mothersRBC alloimmunizationNovel murine modelGlycoprotein antibodiesC57BL/6 recipientsImmunized mothersNegative fetusMurine modelAnimal modelsC57BL/6 femalesMechanisms of immunizationRBC-specific expressionSubset of pregnanciesFlow cytometric crossmatchSubtype-specific antibodiesDays of lifeFirst animal modelAnti-Kell antibodiesPrior pregnancySubsequent transfusionsCytometric crossmatchRBC transfusionAntibody titersRepeat pregnancyRBC antibodies
2010
Fresh Murine Red Blood Cells Abrogate the Enhanced Alloimmunogenicity of Stored Murine Red Blood Cells
Hendrickson J, Hod E, Spitalnik S, Zimring J. Fresh Murine Red Blood Cells Abrogate the Enhanced Alloimmunogenicity of Stored Murine Red Blood Cells. Blood 2010, 116: 663. DOI: 10.1182/blood.v116.21.663.663.Peer-Reviewed Original ResearchFresh red blood cellsStored red blood cellsMurine red blood cellsRed blood cellsOld red blood cellsBlood cellsMurine modelFlow cytometric crossmatchRandomized clinical studyRates of immunizationYoung red blood cellsAdditional control animalsCPDA-1Alloimmunization rateFVB controlsAlloantibody responsesAlloimmune responseC57BL/6 recipientsCytometric crossmatchPotential deleterious effectsImmunoregulatory propertiesWorse outcomesClinical dataClinical studiesAntigen expression