2015
DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2015, 126: 658. DOI: 10.1182/blood.v126.23.658.658.Peer-Reviewed Original ResearchAllogeneic red blood cellsDOCK8-deficient miceRed blood cellsT cellsDendritic cellsT cell activationAllogeneic responseB cellsImmune signalsCell activationT cell receptor transgenic miceSplenic dendritic cell subsetsBlood cellsDendritic cell activityInduction of alloimmunityDendritic cell subsetsHen egg lysozymeT cell primingDendritic cell migrationInnate immune cellsReceptor transgenic miceInnate immune signalsT cell zonesAntigen presenting cellsB cell responses
2014
NLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells
Eisenbarth S, Hendrickson J, Calabro S, Gallman A. NLRP10-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells. Blood 2014, 124: 4113. DOI: 10.1182/blood.v124.21.4113.4113.Peer-Reviewed Original ResearchAllogeneic red blood cellsRed blood cellsDendritic cellsT cell activationT cellsBlood cellsIntegral membrane proteinsAllogeneic responseBeta-globin promoterB cellsImmune signalsTriple fusion proteinCell activationT cell receptor transgenic miceInnate immune cytokine responsesRounds of divisionDendritic cell activityInduction of alloimmunityHen egg lysozymeSplenic dendritic cellsT cell primingReceptor transgenic miceImmune cytokine responsesInnate immune signalsGlobin promoter
2011
Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis
Hudson K, Hendrickson J, Cadwell C, Iwakoshi N, Zimring J. Central T Cell Tolerance and Peripheral B Cell Tolerance for An RBC Autoantigen Are Incomplete in Healthy Mice; Implications for AIHA Pathogenesis. Blood 2011, 118: 693. DOI: 10.1182/blood.v118.21.693.693.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaT cell toleranceOVA/CFAB cell tolerancePathogenesis of AIHAReactive T cellsT cellsHOD antigenAdoptive transferPeripheral toleranceCell toleranceB cellsB6 miceHen egg lysozymeHOD RBCsReactive CD4Humoral toleranceF1 miceImmune responseAntigen expressionTransgenic miceWild-type B6 miceWild-type C57BL/6 micePeripheral B cell toleranceOT-II CD4
2009
Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs.
Hendrickson J, Hod E, Spitalnik S, Hillyer C, Zimring J. Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs. Blood 2009, 114: 640. DOI: 10.1182/blood.v114.22.640.640.Peer-Reviewed Original ResearchWhite blood cellsHOD RBCsPost-transfusion survivalCytometric crossmatchingRBC alloimmunizationLeukoreduction filtersHen egg lysozymeRBC antigensFlow cytometryRBC-specific expressionRed blood cell antigensReductionist murine modelHemolytic transfusion reactionsMinority of miceLateral tail veinAntigen hen egg lysozymeBlood cell antigensEffect of leukoreductionResidual white blood cellsPropridium iodideAltered clearanceHLA alloimmunizationSingle transfusionHLA antigensTransfusion reactions
2005
Host Inflammation Increases Alloimmunization to Transfused Red Blood Cells.
Hendrickson J, Chadwick T, Roback J, Hillyer C, Zimring J. Host Inflammation Increases Alloimmunization to Transfused Red Blood Cells. Blood 2005, 106: 1887. DOI: 10.1182/blood.v106.11.1887.1887.Peer-Reviewed Original ResearchTransfusion recipientsIgG subtypesHen egg lysozymeRecipient miceHost inflammationViral infectionCo-existing infectionsDifferent IgG subtypesHemolytic transfusion reactionsActivation of macrophagesInnate immune systemUnits of RBCsBlood group antigensHumoral immunizationMimic inflammationRecipient inflammationAlloantibody responsesRed blood cellsSerious sequelaeIgG responsesAntibody titersHumoral immunityHumoral responseIgG synthesisImmunomodulatory agents