2008
A Novel Model of Autoimmunity to Self Red Blood Cell Antigens
Hendrickson J, Cadwell C, Hillyer C, Zimring J. A Novel Model of Autoimmunity to Self Red Blood Cell Antigens. Blood 2008, 112: 3461. DOI: 10.1182/blood.v112.11.3461.3461.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaB1 B cellsSelf-reactive B cellsReactive B cellsAutoreactive B cellsB cell toleranceB cellsControl micePositive miceB cell maturationLymph nodesBone marrowCell toleranceRBC antigensCell maturationRBC-specific expressionRed blood cell antigensSystemic immune activationHuman blood group antigensAntigen hen egg lysozymeLife-threatening illnessConventional B cellsBlood cell antigensSigns of illnessHemoglobin breakdown products
2006
Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. Recipient Inflammation That Increases Alloimmunization Also Enhances Consumption of Transfused RBCs by Dendritic Cells. Blood 2006, 108: 23. DOI: 10.1182/blood.v108.11.23.23.Peer-Reviewed Original ResearchLiver dendritic cellsDendritic cellsT cellsRBC antigensRed blood cellsImmune responseSplenic macrophagesB cellsRBC consumptionCo-stimulatory molecule expressionBlood cellsRed blood cell antigensMajority of patientsC57BL/6 recipient micePresence of inflammationAbsence of inflammationRole of antigenLymph node macrophagesBlood cell antigensRBC alloimmunizationRecipient inflammationAlloantibody responsesLymph nodesRBC transfusionPotent APCs