2013
Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models
Hendrickson J. Red Blood Cell Alloimmunization and Hemolytic Disease of the Fetus and Newborn: New Approaches Using Animal Models. Blood 2013, 122: sci-49. DOI: 10.1182/blood.v122.21.sci-49.sci-49.Peer-Reviewed Original ResearchRed blood cellsMurine red blood cellsPreventive therapyRBC alloantibodiesTransfusion settingsRBC precursorsHemolytic diseaseAnimal modelsAntigen-negative red blood cellsNewborn pupsRed blood cell alloimmunizationPositive indirect antiglobulin testBone marrow erythroid precursorsMature red blood cellsFetal liverNegative red blood cellsPotential preventive therapyRBC-specific expressionRh immune globulinFlow cytometric crossmatchPregnancy/deliveryFetus/neonateForeign red blood cellsWeeks of deliveryIndirect antiglobulin test
2012
Marginal Zone B Cells Mediate Alloantibody Formation to a Clinically Significant Human RBC Antigen in a Murine Model
Girard-Pierce K, Stowell S, Smith N, Henry K, Zimring J, Hendrickson J. Marginal Zone B Cells Mediate Alloantibody Formation to a Clinically Significant Human RBC Antigen in a Murine Model. Blood 2012, 120: 843. DOI: 10.1182/blood.v120.21.843.843.Peer-Reviewed Original ResearchMZ B cellsHemolytic transfusion reactionsTransfusion of RBCsC57BL/6 recipient miceRecipient miceAlloimmune responseB cellsRBC antigensRBC alloimmunizationAlloantibody responsesPost transfusionMouse modelRBC clearanceFlow cytometryNovel transgenic mouse modelBlood borne antigensConsequences of alloimmunizationControl recipient miceDays post transfusionHuman KEL glycoproteinRBC-specific expressionB-cell depletionRed blood cell antigensAntibody-mediated immunityMarginal zone B cells
2011
A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization
Smith N, Henry K, Zimring J, Hendrickson J. A Novel Murine Model of Pregnancy and Transfusion Induced Anti-Kell RBC Alloimmunization. Blood 2011, 118: 715. DOI: 10.1182/blood.v118.21.715.715.Peer-Reviewed Original ResearchNon-immunized mothersRBC alloimmunizationNovel murine modelGlycoprotein antibodiesC57BL/6 recipientsImmunized mothersNegative fetusMurine modelAnimal modelsC57BL/6 femalesMechanisms of immunizationRBC-specific expressionSubset of pregnanciesFlow cytometric crossmatchSubtype-specific antibodiesDays of lifeFirst animal modelAnti-Kell antibodiesPrior pregnancySubsequent transfusionsCytometric crossmatchRBC transfusionAntibody titersRepeat pregnancyRBC antibodies
2009
Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs.
Hendrickson J, Hod E, Spitalnik S, Hillyer C, Zimring J. Leukoreduction Decreases Alloimmunogenicity of Transfused Murine HOD RBCs. Blood 2009, 114: 640. DOI: 10.1182/blood.v114.22.640.640.Peer-Reviewed Original ResearchWhite blood cellsHOD RBCsPost-transfusion survivalCytometric crossmatchingRBC alloimmunizationLeukoreduction filtersHen egg lysozymeRBC antigensFlow cytometryRBC-specific expressionRed blood cell antigensReductionist murine modelHemolytic transfusion reactionsMinority of miceLateral tail veinAntigen hen egg lysozymeBlood cell antigensEffect of leukoreductionResidual white blood cellsPropridium iodideAltered clearanceHLA alloimmunizationSingle transfusionHLA antigensTransfusion reactions
2008
A Novel Model of Autoimmunity to Self Red Blood Cell Antigens
Hendrickson J, Cadwell C, Hillyer C, Zimring J. A Novel Model of Autoimmunity to Self Red Blood Cell Antigens. Blood 2008, 112: 3461. DOI: 10.1182/blood.v112.11.3461.3461.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaB1 B cellsSelf-reactive B cellsReactive B cellsAutoreactive B cellsB cell toleranceB cellsControl micePositive miceB cell maturationLymph nodesBone marrowCell toleranceRBC antigensCell maturationRBC-specific expressionRed blood cell antigensSystemic immune activationHuman blood group antigensAntigen hen egg lysozymeLife-threatening illnessConventional B cellsBlood cell antigensSigns of illnessHemoglobin breakdown productsBerkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice
HendricKson J, Archer D, Perry J, Hillyer C, Zimring J. Berkeley Mice with Sickle Cell Disease Are Not More Immunizable to Transfused HOD Red Blood Cells Than Sickle Trait Control Mice. Blood 2008, 112: 292. DOI: 10.1182/blood.v112.11.292.292.Peer-Reviewed Original ResearchCo-stimulatory molecule expressionSickle cell diseaseBerkeley miceAntigen presenting cellsCell diseaseSickle cell traitMolecule expressionForeign antigensRBC alloimmunizationBaseline inflammationDendritic cellsPresenting cellsRed blood cell alloimmunizationCell traitIndividual miceELISA 2 weeksRate of alloimmunizationRBC-specific expressionTransfusion of RBCsHuman blood group antigensLevel of illnessAntigen hen egg lysozymeDonor/recipientHigh rateTime of illness