2019
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation
Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. Nature Genetics 2019, 51: 1233-1243. PMID: 31358993, PMCID: PMC6675645, DOI: 10.1038/s41588-019-0470-3.Peer-Reviewed Original ResearchConceptsEarly-onset atherosclerosisMetabolic syndromeMetabolic syndrome traitsWhole-exome sequence analysisAttractive therapeutic targetPlatelet hyperactivationInsulin levelsPlasma insulinPlasma levelsInsulin sensitivityInsulin secretionTherapeutic targetPlatelet activationDisease mechanismsSyndrome traitsAtherosclerosisFunction mutationsSyndromeNovel lossInsulinMutationsSecretion
2014
Silver Lining in the Dark Cloud of Aneurysm Disease
Chau KH, Bender JR, Elefteriades JA. Silver Lining in the Dark Cloud of Aneurysm Disease. Cardiology 2014, 128: 327-332. PMID: 24942201, DOI: 10.1159/000358123.Peer-Reviewed Original ResearchConceptsAortic aneurysmCarotid intima-media thicknessIntima-media thicknessClinical findingsArterial calcificationAneurysm diseaseAortic rootClinical dataProtective effectPharmacologic evidenceMatrix metalloproteinasesAneurysmsAtherosclerosisEarly indicatorDiseaseMolecular mechanismsEvidencePatientsSilver liningDiagnosisCalcificationMetalloproteinasesGenetic studies
2005
Cytokines and cardiovascular disease
Mehra VC, Ramgolam VS, Bender JR. Cytokines and cardiovascular disease. Journal Of Leukocyte Biology 2005, 78: 805-818. PMID: 16006537, DOI: 10.1189/jlb.0405182.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMyocardial functionNitric oxideMyocardial depressant effectsProgression of atherosclerosisRole of cytokinesRelease of cytokinesArachidonic acid metabolitesInflammatory mechanismsHeart failureInflammatory cascadeDepressant effectCytokine influenceImmune cascadeAcid metabolitesCytokinesBiochemical effectsDiseaseCommon formAtherosclerosisChemokinesReviewPathogenesisProgressionComprehensive reviewInflammatory mechanisms in vascular disease
Mehra V, Ramgolam V, Bender J. Inflammatory mechanisms in vascular disease. Drug Discovery Today Disease Mechanisms 2005, 2: 77-84. DOI: 10.1016/j.ddmec.2005.05.010.Peer-Reviewed Original Research
2000
Molecular mechanisms of estrogen actions on the vasculature
Haynes M, Russell K, Bender J. Molecular mechanisms of estrogen actions on the vasculature. Journal Of Nuclear Cardiology 2000, 7: 500-508. PMID: 11083200, DOI: 10.1067/mnc.2000.109958.Peer-Reviewed Original ResearchConceptsSelective estrogen receptor modulatorsEstrogen receptor modulatorsReceptor modulatorsPlaque-destabilizing effectsEffects of estrogenClinical atherosclerosisPharmacologic therapyVascular responsesMolecular mechanismsEstrogen actionVascular diseaseAnimal studiesBeneficial responseCardiovascular systemEstrogenVascular structuresAdverse effectsVasculatureSpecific pathwaysBroad spectrumAtherosclerosisHistologicInjuryTherapyDisease