2014
The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes
Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R. The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. Journal Of Cell Science 2014, 127: 4381-4395. PMID: 25179599, PMCID: PMC4197085, DOI: 10.1242/jcs.146217.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonActinsAdaptor Proteins, Signal TransducingAnimalsAnimals, Genetically ModifiedCarrier ProteinsCell MovementCell PolarityCells, CulturedLeukocytesMicrotubule-Organizing CenterMultiprotein ComplexesMutationOryziasProtein Kinase CProtein TransportRho-Associated KinasesZebrafishZebrafish ProteinsConceptsAtypical protein kinase CMicrotubule organizing centerPAR-6Par complexPAR-3Protein kinase CRegulated interactionFish larvaeMyeloid cellsGenetic manipulationPolarizing cuesKinase activationCytoskeletal changesF-actinKinase COrganizing centerFunctional polarizationRho kinase activationThree-dimensional environmentTraction forceCellsSpatiotemporal dynamicsLeukocyte migrationMigrationComplexes
2006
Pathophysiology of leukocyte–tissue interactions
Molteni R, Fabbri M, Bender JR, Pardi R. Pathophysiology of leukocyte–tissue interactions. Current Opinion In Cell Biology 2006, 18: 491-498. PMID: 16904306, DOI: 10.1016/j.ceb.2006.08.001.Peer-Reviewed Original Research
2003
Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells
Li L, Haynes MP, Bender JR. Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 4807-4812. PMID: 12682286, PMCID: PMC153637, DOI: 10.1073/pnas.0831079100.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsBase SequenceCell LineCell MembraneCOS CellsEndothelium, VascularEstrogen Receptor alphaGenes, ReporterGenetic VariationHumansNitric Oxide SynthaseNitric Oxide Synthase Type IIIProtein Processing, Post-TranslationalReceptors, EstrogenRecombinant ProteinsRNA, MessengerSubcellular FractionsTranscriptional ActivationTransfectionConceptsPlasma membranePalmitoylation-dependent mannerPlasma membrane localizationInhibition of palmitoylationFull-length ER alphaReporter gene transactivationCOS-7 cellsEndothelial cell proteinsMembrane localizationAlternative splicingEstrogen receptor α variantsOestrogen receptor-alpha variantsN-terminusHuman endothelial cellsCell proteinsER46Synthase pathwayAcid labelingHy926 cellsNonendothelial cellsENOS activationENOS phosphorylationCellsEndothelial cellsMembraneEstrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells
Lei L, Haynes M, Bender J. Estrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells. 2003, 37-45. DOI: 10.1007/978-1-4615-0339-2_5.Peer-Reviewed Original ResearchEndothelial nitric oxide synthaseNitric oxideEndothelial cellsNitric oxide synthaseMembrane estrogen receptorsVascular endothelial cellsEndothelial dysfunctionOxide synthaseEstrogen receptorChronic activationVascular endotheliumLuminal liningPathology 1Vascular cellsMental healthBlood vesselsProtective actionHomeostatic stateReceptorsPivotal rolePertinent chaptersVast majorityCellsDysfunctionReversible phase
1999
A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2
Liu Y, Pan J, Zhang C, Fan W, Collinge M, Bender J, Weissman S. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 4313-4318. PMID: 10200259, PMCID: PMC16329, DOI: 10.1073/pnas.96.8.4313.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsB-LymphocytesBase SequenceCalcium-Binding ProteinsCarrier ProteinsCell Cycle ProteinsCell LineChromosomes, Artificial, YeastCOS CellsGenes, MHC Class IHL-60 CellsHumansJurkat CellsMad2 ProteinsMolecular Sequence DataPolymerase Chain ReactionRepressor ProteinsSequence AlignmentSequence Homology, Amino AcidT-LymphocytesTransfectionTumor Cells, CulturedUbiquitinsConceptsSpindle assembly checkpoint protein Mad2Two-hybrid screeningCheckpoint protein Mad2Ubiquitin-like proteinHuman MHC class I regionCell cycle checkpointsMHC class I regionSpindle assemblyI geneProtein stabilityCell developmentDendritic cell developmentClass I regionImmunoprecipitation studiesCell growthMad2Gamma-interferon inductionProteinProtein expressionFAT10I regionCellsLymphoblastoid linesAnaphaseTranscription
1998
Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion.
Collinge M, Pardi R, Bender J. Class II transactivator-independent endothelial cell MHC class II gene activation induced by lymphocyte adhesion. The Journal Of Immunology 1998, 161: 1589-93. PMID: 9712019, DOI: 10.4049/jimmunol.161.4.1589.Peer-Reviewed Original ResearchConceptsClass II transactivatorNK cellsIFN-gamma-dependent mechanismIFN-gamma-independent mannerLymphocyte adhesionMHC class II expressionHLA-DR alpha mRNAHLA-DR expressionMHC class II moleculesNK cell activationAllogeneic endothelial cellsClass II expressionIFN-gamma-induced MHC class II expressionClass II moleculesAlpha mRNA expressionCell linesHLA-DRIFN-gammaCell activationMRNA expressionEndothelial cellsAlpha mRNACellsPromoter constructsActivation
1987
Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells.
Bender J, Pardi R, Karasek M, Engleman E. Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells. Journal Of Clinical Investigation 1987, 79: 1679-1688. PMID: 3495552, PMCID: PMC424501, DOI: 10.1172/jci113007.Peer-Reviewed Original ResearchConceptsNatural killer cellsMicrovascular endothelial cellsEndothelial cellsKiller cellsE-RFCRosette forming lymphocytesRecombinant interleukin-1Human microvascular endothelial cellsReceptor-ligand interactionsLymphocyte subsetsNK effectorsNK targetsGraft rejectionNK cellsLeu-11Lymphocyte fractionInterleukin-1Microvascular endotheliumSpecific receptor-ligand interactionsAllograftsLymphocytesEC monolayersCritical targetCellsQuantitative adherence