1991
Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium.
Pardi R, Bender J. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium. Circulation Research 1991, 69: 1269-1279. PMID: 1934357, DOI: 10.1161/01.res.69.5.1269.Peer-Reviewed Original ResearchConceptsT cell precursorsEndothelial cellsInterleukin-2T cellsT lymphocytesMicrovascular endotheliumT cell-mediated immune responsesMajor T cell subsetsSpecific cytotoxic T lymphocytesMonocyte/macrophage seriesMHC class II determinantsCD3/T cell receptor complexIndividual cell subsetsGeneration of CD4Effector T cellsClass II determinantsT cell responsesT cell subsetsAdoptive transfer experimentsAllogeneic endothelial cellsClass I determinantsSelf-MHC moleculesCytotoxic T lymphocytesMonocytes/macrophagesT cell receptor complex
1987
Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells.
Bender J, Pardi R, Karasek M, Engleman E. Phenotypic and functional characterization of lymphocytes that bind human microvascular endothelial cells in vitro. Evidence for preferential binding of natural killer cells. Journal Of Clinical Investigation 1987, 79: 1679-1688. PMID: 3495552, PMCID: PMC424501, DOI: 10.1172/jci113007.Peer-Reviewed Original ResearchConceptsNatural killer cellsMicrovascular endothelial cellsEndothelial cellsKiller cellsE-RFCRosette forming lymphocytesRecombinant interleukin-1Human microvascular endothelial cellsReceptor-ligand interactionsLymphocyte subsetsNK effectorsNK targetsGraft rejectionNK cellsLeu-11Lymphocyte fractionInterleukin-1Microvascular endotheliumSpecific receptor-ligand interactionsAllograftsLymphocytesEC monolayersCritical targetCellsQuantitative adherence