2000
CD28 and LFA‐1 contribute to cyclosporin A‐resistant T cell growth by stabilizing the IL‐2 mRNA through distinct signaling pathways
Geginat J, Clissi B, Moro M, Dellabona P, Bender J, Pardi R. CD28 and LFA‐1 contribute to cyclosporin A‐resistant T cell growth by stabilizing the IL‐2 mRNA through distinct signaling pathways. European Journal Of Immunology 2000, 30: 1136-1144. PMID: 10760803, DOI: 10.1002/(sici)1521-4141(200004)30:4<1136::aid-immu1136>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDB7-2 AntigenCalcineurinCD28 AntigensCells, CulturedCyclosporineCytoskeletonDendritic CellsDNA-Binding ProteinsDrug SynergismHumansIntercellular Adhesion Molecule-1Interleukin-2Lymphocyte ActivationLymphocyte Function-Associated Antigen-1Membrane GlycoproteinsMitogen-Activated Protein KinasesNF-kappa BNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticProtein BindingRNA StabilityRNA, MessengerSignal TransductionSuperantigensT-LymphocytesTranscription FactorsConceptsIL-2 mRNALFA-1ICAM-1IL-2 dependentT cell proliferationSubsequent T cell proliferationCostimulatory molecule CD28TCR-induced proliferationSignaling pathwaysT cell growthIL-2 transcriptsGraft rejectionDendritic cellsIL-2Clinical transplantationT lymphocytesMolecule CD28Primary T lymphocytesNF-kappaBCD28Distinct signaling pathwaysLower transcriptional rateDifferent signaling pathwaysProtein kinase activationCell proliferation
1999
Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.
Geginat J, Bossi G, Bender J, Pardi R. Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes. The Journal Of Immunology 1999, 162: 5085-93. PMID: 10227977, DOI: 10.4049/jimmunol.162.9.5085.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalCalcium-Calmodulin-Dependent Protein KinasesCell AdhesionCell CycleCell Cycle ProteinsCell SizeCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDown-RegulationEnzyme ActivationG1 PhaseGene Expression RegulationGenes, fosGenes, junHumansInterleukin-2InterphaseKineticsLymphocyte Function-Associated Antigen-1Microtubule-Associated ProteinsMitogensProtein Serine-Threonine KinasesProto-Oncogene ProteinsReceptors, Antigen, T-CellS PhaseT-LymphocytesTumor Suppressor ProteinsConceptsNormal T cellsT lymphocytesT cellsPrimary T lymphocytesRetinoblastoma protein inactivationCytokines IL-2Function-blocking mAbsIL-2ICAM-1Mitogen-activated protein kinase activationCyclin-dependent kinase inhibitor p27kipIntegrins actMitogenic responseMitogenic cytokinesGrowth factorLymphocytesCell cycle progressionTCR stimulationLate componentsProtein kinase activationLeukocyte integrinsAnchorage dependenceTCR triggeringCycle progressionCellular requirements
1996
Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes.
Bianchi E, Ferrero E, Fazioli F, Mangili F, Wang J, Bender J, Blasi F, Pardi R. Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes. Journal Of Clinical Investigation 1996, 98: 1133-1141. PMID: 8787676, PMCID: PMC507535, DOI: 10.1172/jci118896.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesBreast NeoplasmsCD18 AntigensCell MovementCyclic AMPFemaleFlow CytometryHumansImmunologic CappingIntegrin beta1Lymphocyte ActivationLymphocytes, Tumor-InfiltratingPancreatic NeoplasmsProtein Kinase CReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorRNA, MessengerSecond Messenger SystemsT-LymphocytesUrokinase-Type Plasminogen ActivatorConceptsUrokinase plasminogen activatorAntigen receptor complexProtein kinase C activationAnti-uPAR antibodiesPlasminogen activator/plasmin systemKinase C activationPrimary human tumor specimensRegulated processPrimary T lymphocytesHuman tumor specimensT lymphocytesT cellsUrokinase receptorCell migrationExtracellular matrixReceptor complexC activationProtein levelsSites of inflammationT cell migrationPlasminogen activationCatalytic activationIntracellular cyclic AMPPlasmin systemCyclic AMP
1992
Early recognition of a discordant xenogeneic organ by human circulating lymphocytes.
Inverardi L, Samaja M, Motterlini R, Mangili F, Bender J, Pardi R. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. The Journal Of Immunology 1992, 149: 1416-23. PMID: 1386865, DOI: 10.4049/jimmunol.149.4.1416.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCD3 ComplexCell AdhesionCytotoxicity, ImmunologicEndothelium, VascularHeart TransplantationHumansImmunity, CellularKiller Cells, NaturalLymphocyte Function-Associated Antigen-1Lymphocyte SubsetsMyocardiumRatsReceptors, Antigen, T-CellReceptors, FcReceptors, IgGTransplantation, HeterologousConceptsNK cellsXenogeneic organsCell-mediated immune mechanismsHuman lymphocytesAntibody-independent pathwayLymphocyte phenotypic analysisCell-mediated mechanismsHuman NK cellsNK cell adhesionPretreatment of lymphocytesAnti-CD18 antibodiesDiscordant xenograft rejectionHuman circulating lymphocytesEx vivo modelRat endothelial cellsCD3-CD16Vascular resistanceLymphocyte subsetsXenograft rejectionCirculating lymphocytesCoronary systemEarly recognitionImmune mechanismsT lymphocytesCell sequestration
1991
Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium.
Pardi R, Bender J. Signal requirements for the generation of CD4+ and CD8+ T-cell responses to human allogeneic microvascular endothelium. Circulation Research 1991, 69: 1269-1279. PMID: 1934357, DOI: 10.1161/01.res.69.5.1269.Peer-Reviewed Original ResearchConceptsT cell precursorsEndothelial cellsInterleukin-2T cellsT lymphocytesMicrovascular endotheliumT cell-mediated immune responsesMajor T cell subsetsSpecific cytotoxic T lymphocytesMonocyte/macrophage seriesMHC class II determinantsCD3/T cell receptor complexIndividual cell subsetsGeneration of CD4Effector T cellsClass II determinantsT cell responsesT cell subsetsAdoptive transfer experimentsAllogeneic endothelial cellsClass I determinantsSelf-MHC moleculesCytotoxic T lymphocytesMonocytes/macrophagesT cell receptor complex