1996
Feedback modulation of ligand-engaged alpha L/beta 2 leukocyte integrin (LFA-1) by cyclic AMP-dependent protein kinase.
Rovere P, Inverardi L, Bender J, Pardi R. Feedback modulation of ligand-engaged alpha L/beta 2 leukocyte integrin (LFA-1) by cyclic AMP-dependent protein kinase. The Journal Of Immunology 1996, 156: 2273-9. PMID: 8690918, DOI: 10.4049/jimmunol.156.6.2273.Peer-Reviewed Original ResearchConceptsProtein kinase CAdhesion receptorsKinase CCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCytoskeletal anchoring proteinsIntegrin-dependent activationCAMP-dependent kinase activationIntracellular cAMP elevationCAMP elevationHeterologous cell linesLeukocyte integrinsAnchoring proteinsRegulated processProtein kinaseAdenylyl cyclase isoformsMolecular basisKinase activationIntercellular adhesionF-actinCell deadhesionHuman intercellular adhesion molecule-1LFA-1 receptorsDependent adhesionShort-term regulation
1989
Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets.
Pardi R, Bender J, Dettori C, Giannazza E, Engleman E. Heterogeneous distribution and transmembrane signaling properties of lymphocyte function-associated antigen (LFA-1) in human lymphocyte subsets. The Journal Of Immunology 1989, 143: 3157-66. PMID: 2553807, DOI: 10.4049/jimmunol.143.10.3157.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, DifferentiationCell AdhesionCell MembraneCross-Linking ReagentsEndothelium, VascularHumansHydrolysisInterphaseLymphocyte Function-Associated Antigen-1LymphocytesMembrane GlycoproteinsN-Acetylneuraminic AcidPhosphatidylinositolsReceptors, Leukocyte-AdhesionSialic AcidsSignal TransductionStructure-Activity RelationshipConceptsLymphocyte subsetsLFA-1Lymphocyte function-associated antigenDifferent lymphocyte subsetsHuman lymphocyte subsetsFunction-associated antigenAnti-beta subunit antibodiesCell surface densityPhosphoinositide hydrolysisSialic acid contentSubunit antibodiesVariable expressionIntegrin supergene familyLFA-1 alpha subunitNatural ligandCell bindingNeuraminidase digestionActivation eventsRelative increaseAlpha subunitSupergene familySubsetBeta subunit