1989
Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease
Weiss LM, Movahed LA, Warnke RA, Sklar J. Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease. New England Journal Of Medicine 1989, 320: 502-506. PMID: 2536894, DOI: 10.1056/nejm198902233200806.Peer-Reviewed Original ResearchConceptsReed-Sternberg cellsEpstein-Barr virusHodgkin's diseaseSlot blot hybridizationEBV genomeBiopsy tissueTissue specimensEpstein-Barr viral genomeEBV nucleic acidsBlot hybridizationEBV DNASitu hybridizationSouthern blot hybridizationPositive specimensDiseasePatientsInfected cellsTissueIntense hybridizationSuch tissuesCellsViral genomePrevious studiesMonoclonality
1984
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.
Cleary ML, Chao J, Warnke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 593-597. PMID: 6607475, PMCID: PMC344725, DOI: 10.1073/pnas.81.2.593.Peer-Reviewed Original ResearchConceptsClonal immunoglobulin gene rearrangementsB-cell lymphomaImmunoglobulin gene rearrangementsGene rearrangementsReactive lymphoid processesB-cell originNon-neoplastic specimensSubset of lymphomasTotal cell populationLymph nodesLymphoproliferative disordersNeoplastic lymphocytesCytoplasmic immunoglobulinConventional diagnostic methodsPresence of rearrangementsBiopsy tissueCellular immunoglobulinsDiagnostic criteriaLymphoid processesBiopsy samplesLymphomaAntigenic markersSouthern blot hybridization techniqueBlot hybridization technique