2008
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTranscription FactorsTranslocation, GeneticTrans-SplicingConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCells
2007
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J. Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20001-20006. PMID: 18077430, PMCID: PMC2148412, DOI: 10.1073/pnas.0709986104.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCarrier ProteinsCell LineCell Line, TumorCell ProliferationCell SurvivalCo-Repressor ProteinsDNA-Binding ProteinsFemaleGene FusionGene RearrangementHumansNeoplasm ProteinsNuclear ProteinsPolycomb Repressive Complex 2Sarcoma, Endometrial StromalTranscription FactorsTranslocation, GeneticConceptsAllelic exclusionHistone 3 lysine 27 trimethylationPolycomb group genesChromosomal translocationsLikely functional importanceLysine 27 trimethylationPolycomb protein EZH2Protein EZH2Group genesUnrearranged copyGenetic pathwaysMalignant formNormal proliferation rateJAZF1 geneFunctional importanceGene fusionsCell survivalHEK293 cellsGenesCultured cellsCell growthEndometrial stromal tumorsCellular proliferationCell proliferationSUZ12
1986
Weight Reduction and Left Ventricular Mass
Smith S, Link M, Trela M, Amylon M, Sklar J, Morgan R, Hecht F. Weight Reduction and Left Ventricular Mass. New England Journal Of Medicine 1986, 315: 195-6. PMID: 3487732, DOI: 10.1056/nejm198607173150316.Peer-Reviewed Original Research