2008
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTranscription FactorsTranslocation, GeneticTrans-SplicingConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCells
2007
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J. Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20001-20006. PMID: 18077430, PMCID: PMC2148412, DOI: 10.1073/pnas.0709986104.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCarrier ProteinsCell LineCell Line, TumorCell ProliferationCell SurvivalCo-Repressor ProteinsDNA-Binding ProteinsFemaleGene FusionGene RearrangementHumansNeoplasm ProteinsNuclear ProteinsPolycomb Repressive Complex 2Sarcoma, Endometrial StromalTranscription FactorsTranslocation, GeneticConceptsAllelic exclusionHistone 3 lysine 27 trimethylationPolycomb group genesChromosomal translocationsLikely functional importanceLysine 27 trimethylationPolycomb protein EZH2Protein EZH2Group genesUnrearranged copyGenetic pathwaysMalignant formNormal proliferation rateJAZF1 geneFunctional importanceGene fusionsCell survivalHEK293 cellsGenesCultured cellsCell growthEndometrial stromal tumorsCellular proliferationCell proliferationSUZ12
1989
Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease
Weiss LM, Movahed LA, Warnke RA, Sklar J. Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease. New England Journal Of Medicine 1989, 320: 502-506. PMID: 2536894, DOI: 10.1056/nejm198902233200806.Peer-Reviewed Original ResearchConceptsReed-Sternberg cellsEpstein-Barr virusHodgkin's diseaseSlot blot hybridizationEBV genomeBiopsy tissueTissue specimensEpstein-Barr viral genomeEBV nucleic acidsBlot hybridizationEBV DNASitu hybridizationSouthern blot hybridizationPositive specimensDiseasePatientsInfected cellsTissueIntense hybridizationSuch tissuesCellsViral genomePrevious studiesMonoclonality
1986
Weight Reduction and Left Ventricular Mass
Smith S, Link M, Trela M, Amylon M, Sklar J, Morgan R, Hecht F. Weight Reduction and Left Ventricular Mass. New England Journal Of Medicine 1986, 315: 195-6. PMID: 3487732, DOI: 10.1056/nejm198607173150316.Peer-Reviewed Original Research
1984
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.
Cleary ML, Chao J, Warnke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 593-597. PMID: 6607475, PMCID: PMC344725, DOI: 10.1073/pnas.81.2.593.Peer-Reviewed Original ResearchConceptsClonal immunoglobulin gene rearrangementsB-cell lymphomaImmunoglobulin gene rearrangementsGene rearrangementsReactive lymphoid processesB-cell originNon-neoplastic specimensSubset of lymphomasTotal cell populationLymph nodesLymphoproliferative disordersNeoplastic lymphocytesCytoplasmic immunoglobulinConventional diagnostic methodsPresence of rearrangementsBiopsy tissueCellular immunoglobulinsDiagnostic criteriaLymphoid processesBiopsy samplesLymphomaAntigenic markersSouthern blot hybridization techniqueBlot hybridization technique