2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent studyAssociation of Somatic ATP2A2 Damaging Variants With Grover Disease
Seli D, Ellis K, Goldust M, Shah K, Hu R, Zhou J, McNiff J, Choate K. Association of Somatic ATP2A2 Damaging Variants With Grover Disease. JAMA Dermatology 2023, 159: 745-749. PMID: 37195706, PMCID: PMC10193258, DOI: 10.1001/jamadermatol.2023.1139.Peer-Reviewed Original ResearchConceptsGrover's diseaseGD tissuesSomatic single nucleotide variantsControl tissuesRetrospective case seriesCase series studyAnnotation-dependent depletion scoreConsecutive patientsCase seriesKidney failureHistopathologic findingsAcantholytic disordersOrgan transplantationMAIN OUTCOMEBiopsy tissueSeries studyDarier's diseaseClinical diagnosisParticipant's DNAOlder individualsTissue DNADiseaseDisordersPatientsBiopsyGraft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt M, Held W, McNiff J, Jain D, Höfer T, Shlomchik W. Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. Immunity 2023, 56: 369-385.e6. PMID: 36720219, PMCID: PMC10182785, DOI: 10.1016/j.immuni.2023.01.003.Peer-Reviewed Original ResearchConceptsHost diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationChronic antigen stimulationStem cell transplantationAlloreactive effectorsAdoptive transferCell transplantationΑβ TAntigen stimulationCell exhaustionGVHDRecipient tissuesEffector poolMajor causeCell clonesTarget tissuesAffected tissuesDiseaseGraftTissueTCF-1CellsDiseased tissuesMorbidity
2022
Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings
Roy S, Sarhan J, Liu X, Murphy M, Bunick C, Choate K, Damsky W, McNiff J. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. British Journal Of Dermatology 2022, 188: 574-576. PMID: 36763786, DOI: 10.1093/bjd/ljac146.Peer-Reviewed Original ResearchConceptsVirus infectionUnusual clinical findingsElectron microscopy findingsEccrine epitheliumSquamous syringometaplasiaClinical findingsSitu hybridizationEccrine ductsMicroscopy findingsSyringometaplasiaUltrastructural characteristicsInfectionViral mRNAsFindingsPatientsHistopathologicalDiseaseEpithelium
1999
Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.
Grossman D, McNiff J, Li F, Altieri D. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Laboratory Investigation 1999, 79: 1121-6. PMID: 10496530.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaNonmelanoma skin cancerHypertrophic actinic keratosisCell carcinomaSkin cancerKeratinocyte cell lineCutaneous squamous cell carcinomaG0/G1 fractionCell linesAdvanced diseaseBowen's diseaseActinic keratosisSurvivin dominant-negative mutantPremalignant lesionsTherapeutic targetingApoptosis inhibitor survivinSurvivin expressionFlow cytometryWestern blottingDecreased levelsMorpheaform subtypesCancerSpontaneous apoptosisDiseasePrevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells
Shlomchik W, Couzens M, Tang C, McNiff J, Robert M, Liu J, Shlomchik M, Emerson S. Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells. Science 1999, 285: 412-415. PMID: 10411505, DOI: 10.1126/science.285.5426.412.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationBone marrow transplantationHost diseaseMarrow transplantationT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelHost-derived antigen-presenting cellsGraft Versus Host DiseaseHost antigen-presenting cellsDonor antigen-presenting cellsVersus Host DiseaseDonor T cellsAllogeneic T cellsBone marrow transplantation modelAlloimmune attackHost antigensTransplantation modelImportant toxicityNeoplastic diseaseDiseaseGraftTransplantationHost tissuesExtracorporeal photochemotherapy in human and murine graft-versus-host disease
Girardi M, McNiff J, Heald P. Extracorporeal photochemotherapy in human and murine graft-versus-host disease. Journal Of Dermatological Science 1999, 19: 106-113. PMID: 10098701, DOI: 10.1016/s0923-1811(98)00066-8.Peer-Reviewed Original Research
1998
Mycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis?
McNiff J, Schechner J, Crotty P, Glusac E. Mycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis? American Journal Of Dermatopathology 1998, 20: 271-275. PMID: 9650701, DOI: 10.1097/00000372-199806000-00009.Peer-Reviewed Original ResearchConceptsMycosis fungoides palmaris et plantarisWoringer-Kolopp diseasePalmaris et plantarisPagetoid reticulosisEpidermotropic atypical lymphocytesPolymerase chain reaction studiesT-cell receptor betaT-cell clonalityClonal gene rearrangementsEpidermotropic lymphocytesRecurrent plaquesAtypical lymphocytesCutaneous plaquesSuppressor/Dermal infiltrateMycosis fungoidesSystemic diseaseAcral sitesT cellsBiologic potentialHistologic resemblanceIntraepidermal lymphocytesReceptor betaDiseasePlantaris