2009
Donor APCs Promote Gvhd in MHC-Mismatched Transplants by Indirectly Presenting Host Minor Histocompatibility Antigens.
Wang X, Martone C, Demetris A, McNiff J, Shlomchik W. Donor APCs Promote Gvhd in MHC-Mismatched Transplants by Indirectly Presenting Host Minor Histocompatibility Antigens. Blood 2009, 114: 689. DOI: 10.1182/blood.v114.22.689.689.Peer-Reviewed Original ResearchAntigen presenting cellsBALB/c miceHost minor histocompatibility antigensCD4 cellsMinor histocompatibility antigensT cellsC miceAcute GVHDAllogeneic MHCChronic GVHDDonor BMHistocompatibility antigensIndirect presentationFemale recipientsT cell receptor transgenic T cellsDay 7Bone marrow/stem cell transplantationFemale BALB/c miceHost antigen presenting cellsMale BALB/c miceRecipient antigen presenting cellsBALB/c modelAlloreactive CD4 cellsPrime T cellsStem cell transplantation
2005
CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL.
Shlomchik W, Matte C, Liu J, Jain D, McNiff J. CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL. Blood 2005, 106: 580. DOI: 10.1182/blood.v106.11.580.580.Peer-Reviewed Original ResearchCD8-mediated GVHDDirect cognate interactionT cellsSecond transplantCD4 cellsCD8 cellsHost antigensCognate interactionMHCII expressionBone marrowDonor CD4 cellsDonor-derived APCsT-cell releaseTarget tissuesAlloreactive T cellsBone marrow chimerasMinor H antigensCognate T cellsChimeric recipientsDonor BMGVHD lethalityHistologic GVHDHost APCsLess GVHDLeukemic expression
2004
Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ.
Anderson B, McNiff J, Jain D, Blazar B, Shlomchik W, Shlomchik M. Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ. Blood 2004, 104: 3059. DOI: 10.1182/blood.v104.11.3059.3059.Peer-Reviewed Original ResearchChronic GVHDCutaneous chronic GVHDHost APCsCD4 cellsWT BMDonor APCsAcute GVHDHost diseaseRecipient APCsAPC requirementsHost antigen presenting cellsAllogeneic stem cell transplantationChronic Graft-vsDonor CD4 cellsPre-transplant weightDonor T cellsStem cell transplantationCostimulatory molecules CD80Antigen presenting cellsSite of diseaseChimeric recipientsCutaneous GVHDDonor BMGraft-vsGVHD prevention