2011
A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6)
Juchem K, Anderson B, Zhang C, McNiff J, Demetris A, Caton A, Shlomchik W, Shlomchik M. A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6). The Journal Of Immunology 2011, 186: 169.6-169.6. DOI: 10.4049/jimmunol.186.supp.169.6.Peer-Reviewed Original ResearchMemory T cellsEffector memory T cellsT cellsGVHD inductionAllogeneic stem cell transplantationMemory T cell poolCentral memory T cellsT cell receptor transgenicT cell receptor repertoireT cell poolStem cell transplantationCell receptor repertoireNaïve T cellsTg T cellsSyngeneic bone marrowCell-intrinsic defectTransient GVHDHost diseasePost transplantMajor complicationsPD-1PD-L1Transgenic recipientsCell transplantationNaive CD4
2008
Redundant Mechanisms for Dendritic Cell Activation in GVHD Induction: Signalings Via TLRs, TNF-α, IL-1 and CD40 Are Not Required
Li H, Matte-Martone C, Demetris A, McNiff J, Jain D, Shlomchik W. Redundant Mechanisms for Dendritic Cell Activation in GVHD Induction: Signalings Via TLRs, TNF-α, IL-1 and CD40 Are Not Required. Blood 2008, 112: 3509. DOI: 10.1182/blood.v112.11.3509.3509.Peer-Reviewed Original ResearchHost antigen-presenting cellsAntigen-presenting cellsToll-like receptorsDC maturation signalsDonor T cellsDendritic cellsT cellsT cell activationMaturation signalsCell activationGVHD inductionHistologic GVHDMyD88/DC maturationAPC maturationIL-1Alloreactive donor T cellsAlloreactive T cell activationAdaptive T cell responsesAllogeneic stem cell transplantationHost hematopoietic cellsTNFR1/R2WT B6 miceDendritic cell activationT cell primingRecipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation
Li H, Kaplan D, Demetris A, McNiff J, Shlomchik M, Shlomchik W. Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation. Blood 2008, 112: 3511. DOI: 10.1182/blood.v112.11.3511.3511.Peer-Reviewed Original ResearchRecipient antigen-presenting cellsHost Langerhans cellsAntigen-presenting cellsBone marrow transplantAllogeneic bone marrow transplantRecipient Langerhans cellsDonor T cellsGVHD inductionEpidermal Langerhans cellsLangerhans cellsBone marrowSkin GVHDMarrow transplantT cellsAllogeneic donor T cellsAlloreactive donor T cellsDonor-derived Langerhans cellsMajor antigen-presenting cellsHost antigen-presenting cellsProfessional antigen-presenting cellsWeight lossDonor Langerhans cellsExpression of langerinTime of transplantUV-induced inflammation