2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
2019
Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria
Roy SF, Dong D, Myung P, McNiff JM. Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. Journal Of Cutaneous Pathology 2019, 46: 563-569. PMID: 30927287, DOI: 10.1111/cup.13463.Peer-Reviewed Original ResearchConceptsMultinucleate cell angiohistiocytomaFollicular inductionDiagnostic criteriaPapillary dermal vesselsMononuclear inflammatory infiltrateHistologic diagnostic criteriaLarge case seriesSpecific histologic criteriaWnt/ß-cateninClinicopathologic studyPerifollicular fibrosisCase seriesHistopathologic evidenceInflammatory infiltrateUnderdiagnosed entityFibrohistiocytic originInflamed lesionsHistologic criteriaDermal vesselsHistopathologic entityDermatopathology laboratoryDermatofibromaß-cateninPossible alterationsFibrosis