2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
1997
Discoid Lupus Erythematosus Presenting as Asymmetric Posterior Blepharitis
Gloor P, Kim M, McNiff J, Wolfley D. Discoid Lupus Erythematosus Presenting as Asymmetric Posterior Blepharitis. American Journal Of Ophthalmology 1997, 124: 707-709. PMID: 9372736, DOI: 10.1016/s0002-9394(14)70920-1.Peer-Reviewed Original ResearchConceptsDiscoid lupus erythematosusLupus erythematosusPosterior blepharitisSystemic lupus erythematosusCutaneous biopsy specimensDiscoid lupusOphthalmic findingsCutaneous lesionsBiopsy specimensEyelid biopsyEyelid marginErythematosusImmunofluorescence studiesBlepharitisPatientsMisdiagnosisDiagnosisEyelidPresentingBiopsyLupusHistologyLesionsDeformityWomen