Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation
Li H, Kaplan D, Demetris A, McNiff J, Shlomchik M, Shlomchik W. Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation. Blood 2008, 112: 3511. DOI: 10.1182/blood.v112.11.3511.3511.Peer-Reviewed Original ResearchRecipient antigen-presenting cellsHost Langerhans cellsAntigen-presenting cellsBone marrow transplantAllogeneic bone marrow transplantRecipient Langerhans cellsDonor T cellsGVHD inductionEpidermal Langerhans cellsLangerhans cellsBone marrowSkin GVHDMarrow transplantT cellsAllogeneic donor T cellsAlloreactive donor T cellsDonor-derived Langerhans cellsMajor antigen-presenting cellsHost antigen-presenting cellsProfessional antigen-presenting cellsWeight lossDonor Langerhans cellsExpression of langerinTime of transplantUV-induced inflammation